Glyoxylate and dicarboxylate metabolism information
Glyoxylate and dicarboxylate metabolism describes a variety of reactions involving glyoxylate or dicarboxylates. Glyoxylate is the conjugate base of glyoxylic acid, and within a buffered environment of known pH such as the cell cytoplasm these terms can be used almost interchangeably, as the gain or loss of a hydrogen ion is all that distinguishes them, and this can occur in the aqueous environment at any time. Likewise dicarboxylates are the conjugate bases of dicarboxylic acids, a general class of organic compounds containing two carboxylic acid groups, such as oxalic acid or succinic acid.
A compact graphical description of major biochemical reactions involved can be found at KEGG[1] This provides information on the relevant enzymes and details the relationship with several other metabolic processes: glycine, serine, and threonine metabolism which provides hydroxypyruvate and glyoxylate, purine metabolism which provides glyoxylate, pyruvate metabolism which provides (S)-malate and formate, carbon fixation which consumes 3-phospho-D-glycerate and provides D-ribulose 1,5-P2, ascorbate and aldarate metabolism which shares tartronate-semialdehyde, nitrogen metabolism which shares formate, pyruvate metabolism and the citrate cycle which share oxaloacetate, and vitamin B6 metabolism which consumes glycolaldehyde.
The glyoxylate cycle describes an important subset of these reactions involved in biosynthesis of carbohydrates from fatty acids or two-carbon precursors which enter the system as acetyl-coenzyme A. Its crucial enzymes are isocitrate lyase and malate synthase. However, alternate pathways have been proposed in organisms lacking isocitrate lyase.[2]
^"Glyoxylate and dicarboxylate metabolism". at KEGG.
^"Subsystem: Glyoxylate bypass". National Microbial Pathogen Data Resource. Archived from the original on 2011-10-05.
and 18 Related for: Glyoxylate and dicarboxylate metabolism information
Glyoxylateanddicarboxylatemetabolism describes a variety of reactions involving glyoxylate or dicarboxylates. Glyoxylate is the conjugate base of glyoxylic...
threo-Ds-isocitrate glyoxylate-lyase, and isocitrate glyoxylate-lyase. This enzyme participates in glyoxylateanddicarboxylatemetabolism. This enzyme belongs...
participates in glycine, serine and threonine metabolism and glyoxylateanddicarboxylatemetabolism. This class of enzyme is part of a larger superfamily of...
include aero-oxalo dehydrogenase, and oxalic acid oxidase. This enzyme participates in glyoxylateanddicarboxylatemetabolism. It uses Manganese as a cofactor...
3-oxalomalate glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylatemetabolism. Sekizawa Y, Maragoudakis ME, King TE, Cheldelin VH (1966). "Glutamate...
formamidase, formamidase I, and formamidase II. This enzyme participates in tryptophan metabolismandglyoxylateanddicarboxylatemetabolism. HAYAISHI O, STANIER...
reductase, and D-glycerate dehydrogenase. This enzyme participates in glycine, serine and threonine metabolismandglyoxylateanddicarboxylatemetabolism. Biology...
called oxalate carboxy-lyase. This enzyme participates in glyoxylateanddicarboxylatemetabolism. As of late 2007, 5 structures have been solved for this...
bidirectional hydrogenase, and hydrogenase. This enzyme participates in glyoxylateanddicarboxylatemetabolismand methane metabolism. It has 6 cofactors:...
hydroxypyruvate carboxy-lyase. This enzyme participates in glyoxylateanddicarboxylatemetabolism. HEDRICK JL, SALLACH HJ (1964). "THE NONOXIDATIVE DECARBOXYLATION...
oxidoreductase, and L-lactaldehyde:propanediol oxidoreductase. This enzyme participates in pyruvate metabolismandglyoxylateanddicarboxylatemetabolism. As of...
formylase II). This enzyme participates in histidine metabolismandglyoxylateanddicarboxylatemetabolism. Ohmura E, Hayaishi O (1957). "Enzymatic conversion...
enzyme participates in glyoxylate and dicarboxylatemetabolism. de Windt FE, van der Drift C (1980). "Purification and some properties of hydroxypyruvate...
mesotartrate dehydrogenase. This enzyme participates in glyoxylateanddicarboxylatemetabolism. It employs one cofactor, manganese. Kohn LD, Packman PM...
participates in glyoxylateanddicarboxylatemetabolism. Sly WS, Stadtman ER (1963). "Formate metabolism. II. Enzymatic synthesis of formyl phosphate and formyl...
enzyme participates in glyoxylateanddicarboxylatemetabolism. Fukumaga K (1960). "Metabolism of dihydroxyfumarate, hydroxypyruvate, and their related compounds...
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