Geoffrey Chang is a professor at the University of California, San Diego's Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine. His laboratory focuses on the structural biology of integral membrane proteins, particularly exploring X-ray crystallography techniques for solving the tertiary structures of membrane proteins that are notoriously resistant to crystallization. The laboratory has specialized in structures of multidrug resistance transporter proteins in bacteria. In 2001, while a faculty member of The Scripps Research Institute, Chang was awarded a Beckman Young Investigators Award,[1] designed to support researchers early in their academic careers, for his work on the structural biology of multidrug resistance.[2] Chang announced a move from Scripps to neighboring UC San Diego in 2012.[3]
In 2007, Chang and coauthors retracted five previously published papers describing the structures of three multidrug transporter proteins after another research group published a widely differing structure, which led to the discovery of a critical bug in the Chang group's custom software tools.[4] Since that time, however, Chang has published other papers in the field of structural biology,[5][6] and has been awarded a EUREKA grant, "for exceptionally innovative research projects that could have an extraordinarily significant impact on many areas of science," from the National Institutes of Health.[7]
^"Geoffrey Chang". Arnold and Mabel Beckman Foundation. Retrieved 1 August 2018.
^The Scripps Research Institute News and Views. In Brief 1(9): 2 Apr 2001. Access date 17 Jan 2001.
^Robbins, Gary (9 Oct 2012). "Scripps Research Loses Fifth Talented Scientist". San Diego Union-Tribune. Retrieved 10 February 2015.
^Miller, G (2006). "Scientific publishing. A scientist's nightmare: software problem leads to five retractions". Science. 314 (5807): 1856–7. doi:10.1126/science.314.5807.1856. PMID 17185570. S2CID 34054520.
^Aller, S.; et al. (2009). "Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding". Science. 323 (5922): 1718–1722. Bibcode:2009Sci...323.1718A. doi:10.1126/science.1168750. PMC 2720052. PMID 19325113.
^He et al., "Structure of a Cation‐bound Multidrug and Toxic Compound Extrusion Transporter," http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature09408.html
^Scripps Research Institute Geoffrey Chang Wins EUREKA Award http://www.scripps.edu/newsandviews/e_20100920/etc.html
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