Gedunin information

Gedunin
Names
	IUPAC name Gedunin
	Systematic IUPAC name [(1S,2R,4S,7S,8S,11R,12R,17R,19R)-7-(furan-3-yl)-1,8,12,16,16-pentamethyl-5,15-dioxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-en-19-yl] acetate
	Other names Gedunine; (-)-Gedunin; (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-1-(Furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Gedunin is a pentacyclic triterpenoid with the molecular formula C₂₈H₃₄O₇. It is most notably found in Azadirachta indica,^[1] but is a constituent of several other plants. Gedunin shows therapeutic potential in the treatment of leukemia,^[2] and Parkinson's disease.^[3]^[4]

^ Hallur, Gurulingappa; Sivramakrishnan, Apoorba; Bhat, Sujata V. (2002-08-01). "Three New Tetranortriterpenoids from Neem Seed Oil". Journal of Natural Products. 65 (8): 1177–1179. doi:10.1021/np0105174. ISSN 0163-3864. PMID 12193026.
^ Kikuchi, Takashi; Ishii, Koichi; Noto, Taisuke; Takahashi, Akitomo; Tabata, Keiichi; Suzuki, Takashi; Akihisa, Toshihiro (2011-04-25). "Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem)". Journal of Natural Products. 74 (4): 866–870. doi:10.1021/np100783k. ISSN 1520-6025. PMID 21381696.
^ Rane, Anand; Rajagopalan, Subramanian; Ahuja, Manuj; Thomas, Bobby; Chinta, Shankar J.; Andersen, Julie K. (March 2018). "Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease". Neurotoxicology. 65: 166–173. doi:10.1016/j.neuro.2018.02.012. ISSN 1872-9711. PMC 5857252. PMID 29471019.
^ Zhou, Heying; Li, Fengxia; Li, Yanli (November 2022). "Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells". Applied Biochemistry and Biotechnology. 194 (11): 5322–5332. doi:10.1007/s12010-022-04001-8. ISSN 1559-0291. PMID 35759172. S2CID 250065297.

[1] Hallur, Gurulingappa; Sivramakrishnan, Apoorba; Bhat, Sujata V. (2002-08-01). "Three New Tetranortriterpenoids from Neem Seed Oil". Journal of Natural Products. 65 (8): 1177–1179. doi:10.1021/np0105174. ISSN 0163-3864. PMID 12193026.

[2] Kikuchi, Takashi; Ishii, Koichi; Noto, Taisuke; Takahashi, Akitomo; Tabata, Keiichi; Suzuki, Takashi; Akihisa, Toshihiro (2011-04-25). "Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem)". Journal of Natural Products. 74 (4): 866–870. doi:10.1021/np100783k. ISSN 1520-6025. PMID 21381696.

[3] Rane, Anand; Rajagopalan, Subramanian; Ahuja, Manuj; Thomas, Bobby; Chinta, Shankar J.; Andersen, Julie K. (March 2018). "Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease". Neurotoxicology. 65: 166–173. doi:10.1016/j.neuro.2018.02.012. ISSN 1872-9711. PMC 5857252. PMID 29471019.

[4] Zhou, Heying; Li, Fengxia; Li, Yanli (November 2022). "Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells". Applied Biochemistry and Biotechnology. 194 (11): 5322–5332. doi:10.1007/s12010-022-04001-8. ISSN 1559-0291. PMID 35759172. S2CID 250065297.

Gedunin information

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Gedunin

Deoxygedunin

Names

IUPAC name Gedunin
Systematic IUPAC name [(1S,2R,4S,7S,8S,11R,12R,17R,19R)-7-(furan-3-yl)-1,8,12,16,16-pentamethyl-5,15-dioxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-en-19-yl] acetate
Other names Gedunine (-)-Gedunin (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-1-(Furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references