GW501516 (also known as GW-501,516, GW1516, GSK-516, Cardarine, and on the black market as Endurobol[1]) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. It entered into clinical development as a drug candidate for metabolic and cardiovascular diseases, but was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.[2]
In 2007, research was published showing that high doses of GW501516 given to mice dramatically improved their physical performance; the work was widely discussed in popular media, and led to a black market for the drug candidate and to its abuse by athletes as a doping agent. The World Anti-Doping Agency (WADA) developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009; it has issued additional warnings to athletes that GW501516 is not safe.
^Koh B (2013-03-22). "Anti-doping agency warns cheats on the health risks of Endurobol". The Conversation.
^Cite error: The named reference Sahebkar2014rev was invoked but never defined (see the help page).
GW501516 (also known as GW-501,516, GW1516, GSK-516, Cardarine, and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in...
SR9011 drug are described as "Hormone and Metabolic Modulators". GSK4112 GW501516 SR8278 SR9011 Dodson B (2013-08-20). "New drug mimics the beneficial effects...
in June 2019. Prior to the scheduled fight, Miller tested positive for GW501516, causing the New York State Athletic Commission (NYSAC) to deny him a license...
its links to immune system function, inflammation and cancer. GSK-4112 GW501516 Nidufexor SR8278 SR9009 Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin...
asthma. PPARδ (delta) is the main target of a research chemical named GW501516. It has been shown that agonism of PPARδ changes the body's fuel preference...
Ciclista a Costa Rica GW501516 2 years 27 & 29 December Steven Villalobos Azofeifa (CRC) Road Vuelta Ciclista a Costa Rica GW501516 2 years 28 December...
include ibutamoren (MK-677), which increases secretion of growth hormone; GW501516 (cardarine), an exercise mimetic that works as an agonist of the PPARβ/δ;...
beat the count the second time. Eventually, Miller tested positive for GW501516 prior his next fight against Anthony Joshua, causing the New York State...
December 17, 2023 Felipe Bunes Felipinho Flyweight June 17, 2023 6 months GW501516 NSAC December 17, 2023 $326 in legal fees Walt Harris The Big Ticket Heavyweight...
completion due to safety findings in rodent studies. Elafibranor GW0742 GW501516 MBX-8025 Peroxisome proliferator-activated receptor US abandoned 7105551...
(Women's marathon) Nursultan Alymkulov Kyrgyzstan Ju-jitsu Metandienone and GW501516 (Men's ne-waza 77 kg) Kumush Yuldashova Uzbekistan Kurash Stanozolol (Women's...
and Dimitry Sokolov. Kaykov tested positive for the black market drug GW501516 in an out-of-competition control on 17 March 2013, and was subsequently...
Radenska squad. Ubeto was provisionally suspended for an adverse finding of GW501516. He was later banned for two years. Broeckx joined the team on 1 August...
Caracas-born Ubeto was provisionally suspended for an adverse finding of GW501516. He was later banned for two years, before being reduced to 14 months....
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