extracellularly glutamate-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
AMPA glutamate receptor activity
protein binding
amyloid-beta binding
signaling receptor activity
Cellular component
extracellular vesicle
integral component of membrane
endocytic vesicle membrane
postsynaptic membrane
cell projection
membrane
plasma membrane
synapse
cell junction
dendrite
AMPA glutamate receptor complex
neuronal cell body
dendritic spine
Biological process
glutamate receptor signaling pathway
ion transport
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
excitatory postsynaptic potential
transport
regulation of NMDA receptor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2893
14802
Ensembl
ENSG00000152578
ENSMUSG00000025892
UniProt
P48058
Q9Z2W8
RefSeq (mRNA)
NM_000829 NM_001077243 NM_001077244 NM_001112812
NM_001113180 NM_001113181 NM_019691
RefSeq (protein)
NP_000820 NP_001070711 NP_001070712 NP_001106283
NP_001106651 NP_001106652 NP_062665
Location (UCSC)
Chr 11: 105.61 – 105.98 Mb
Chr 9: 4.42 – 4.8 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.[5]
This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5] Like the other AMPA receptor subunits, GluA4 occurs as flip and flop spliced variant.[6] In addition, GluA4 CTD long and short isoforms exist, and presumably an ATD-only isoform (433 aa).[7]
^ abcGRCh38: Ensembl release 89: ENSG00000152578 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025892 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference pmid7992055 was invoked but never defined (see the help page).
^Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. ISSN 1420-682X. PMC 8257547. PMID 34100982.
Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene. This gene is a member of a family of L-glutamate-gated ion channels that...
GRIA2 (also named GluA2 or GluR2), GRIA3 (Also named GluA3 or GluR3), and GRIA4 (also called GluA4 or GluRA-D2 ), which combine to form tetramers. Most...
subunits, designated as GluR1 (GRIA1), GluR2 (GRIA2), GluR3 (GRIA3), and GluR4(GRIA4) which combine to form tetramers. They are usually heterotrimeric but can...
spinocerebellar ataxia-14 (SCA14). PRKCG has been shown to interact with GRIA4. Protein kinase C GRCh38: Ensembl release 89: ENSG00000126583 – Ensembl...
have been implicated in autism. CACNG2 has been shown to interact with GRIA4, DLG4, and MAGI2. Voltage-dependent calcium channel GRCh38: Ensembl release...
Global Information
