GRHPR information

GRHPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GCG, 2H1S, 2Q50, 2WWR
Identifiers
Aliases	GRHPR, GLXR, GLYD, PH2, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate and hydroxypyruvate reductase
External IDs	OMIM: 604296; MGI: 1923488; HomoloGene: 49088; GeneCards: GRHPR; OMA:GRHPR - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	37,436,990 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	44,990,734 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; tendon of biceps brachii; ; human kidney; ; muscle of thigh; ; apex of heart; ; C1 segment;
	Top expressed in
	left lobe of liver; ; right kidney; ; proximal tubule; ; Ileal epithelium; ; human kidney; ; adrenal gland; ; yolk sac; ; cumulus cell; ; epithelium of stomach; ; brown adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glycerate dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein homodimerization activity; NAD binding; carboxylic acid binding; NADP binding; NADPH binding; oxidoreductase activity; hydroxypyruvate reductase activity; glyoxylate reductase (NADP+) activity;
Cellular component	cytoplasm; peroxisomal matrix; extracellular exosome; cytosol;
Biological process	dicarboxylic acid metabolic process; excretion; protein complex oligomerization; metabolism; cellular nitrogen compound metabolic process; glyoxylate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9380
	76238
	ENSG00000137106
	ENSMUSG00000035637
	Q9UBQ7
	Q91Z53
	NM_012203
	NM_080289; NM_001312880
	NP_036335
	NP_001299809; NP_525028
	Wikidata
View/Edit Human	View/Edit Mouse

Glyoxylate reductase/hydroxypyruvate reductase is an enzyme that in humans is encoded by the GRHPR gene.^[5]^[6]^[7]

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.^[7] GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137106 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035637 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rumsby G, Cregeen DP (Nov 1999). "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase". Biochim Biophys Acta. 1446 (3): 383–8. doi:10.1016/S0167-4781(99)00105-0. PMID 10524214.
^ Cramer SD, Ferree PM, Lin K, Milliner DS, Holmes RP (Dec 1999). "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II". Hum Mol Genet. 8 (11): 2063–9. doi:10.1093/hmg/8.11.2063. PMID 10484776.
^ ^a ^b "Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase".
^ Takaoka N, Takayama T, Miyazaki M, Nagata M, Ozono S (Dec 2008). "Modification of primers for GRHPR genotyping: avoiding allele dropout by single nucleotide polymorphisms and homology sequence". Urol Res. 36 (6): 297–302. doi:10.1007/s00240-008-0159-z. PMID 18982322. S2CID 12234158.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137106 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035637 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10524214-5] Rumsby G, Cregeen DP (Nov 1999). "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase". Biochim Biophys Acta. 1446 (3): 383–8. doi:10.1016/S0167-4781(99)00105-0. PMID 10524214.

[pmid10484776-6] Cramer SD, Ferree PM, Lin K, Milliner DS, Holmes RP (Dec 1999). "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II". Hum Mol Genet. 8 (11): 2063–9. doi:10.1093/hmg/8.11.2063. PMID 10484776.

[entrez-7] "Entrez Gene: GRHPR glyoxylate reductase/hydroxypyruvate reductase".

[pmid18982322-8] Takaoka N, Takayama T, Miyazaki M, Nagata M, Ozono S (Dec 2008). "Modification of primers for GRHPR genotyping: avoiding allele dropout by single nucleotide polymorphisms and homology sequence". Urol Res. 36 (6): 297–302. doi:10.1007/s00240-008-0159-z. PMID 18982322. S2CID 12234158.

GRHPR information

and 8 Related for: GRHPR information

GRHPR

Glyoxylate reductase

Glycerate dehydrogenase

Primary hyperoxaluria

List of genetic disorders

Hyperoxaluria

Chromosome 9

List of OMIM disorder codes