GOT2 information

GOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AX8
Identifiers
Aliases	GOT2, KAT4, KATIV, mitAAT, KYAT4, glutamic-oxaloacetic transaminase 2, DEE82
External IDs	OMIM: 138150; MGI: 95792; HomoloGene: 1572; GeneCards: GOT2; OMA:GOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	58,734,342 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	96,615,175 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; myocardium of left ventricle; ; right ventricle; ; gastrocnemius muscle; ; triceps brachii muscle; ; apex of heart; ; vastus lateralis muscle; ; middle temporal gyrus; ; right auricle; ; glutes;
	Top expressed in
	lip; ; superior frontal gyrus; ; yolk sac; ; inner renal medulla; ; cerebellar cortex; ; proximal tubule; ; esophagus; ; neural tube; ; connecting tubule; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; catalytic activity; carboxylic acid binding; amino acid binding; enzyme binding; transaminase activity; transferase activity; kynurenine-oxoglutarate transaminase activity; phospholipid binding; L-phenylalanine:2-oxoglutarate aminotransferase activity; L-aspartate:2-oxoglutarate aminotransferase activity; RNA binding; pyridoxal phosphate binding; 4-hydroxyglutamate transaminase activity;
Cellular component	perikaryon; myelin sheath; mitochondrial inner membrane; membrane; cell surface; extracellular exosome; mitochondrial matrix; plasma membrane; mitochondrion; T-tubule; protein-containing complex; sarcolemma;
Biological process	fatty acid transport; cellular amino acid biosynthetic process; oxaloacetate metabolic process; dicarboxylic acid metabolic process; lipid transport; response to ethanol; gluconeogenesis; cellular amino acid metabolic process; glutamate metabolic process; aspartate biosynthetic process; L-kynurenine metabolic process; biosynthesis; glutamate catabolic process to aspartate; aspartate catabolic process; glutamate catabolic process to 2-oxoglutarate; 2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; aspartate metabolic process; glyoxylate metabolic process; transport; female pregnancy; lactation; response to muscle activity; response to insulin; response to morphine;
	Sources:Amigo / QuickGO
Orthologs
	2806
	14719
	ENSG00000125166
	ENSMUSG00000031672
	P00505
	P05202
	NM_002080; NM_001286220
	NM_010325
	NP_001273149; NP_002071
	NP_034455
	Wikidata
View/Edit Human	View/Edit Mouse

Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and Kreb's cycle. Also, GOT2 is a major participant in the malate-aspartate shuttle, which is a passage from the cytosol to the mitochondria. The two enzymes are homodimeric and show close homology.^[5] GOT2 has been seen to have a role in cell proliferation, especially in terms of tumor growth.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125166 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031672 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125166 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)".

GOT2 information

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