Protein
GLS2 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases GLS2 , GA, GLS, LGA, hLGA, glutaminase 2External IDs OMIM: 606365; MGI: 2143539; HomoloGene: 40861; GeneCards: GLS2; OMA:GLS2 - orthologs Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,470,944 bp[1] End 56,488,414 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,030,326 bp[2] End 128,045,873 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver cerebellar hemisphere right hemisphere of cerebellum body of pancreas right frontal lobe oocyte primary visual cortex testicle Brodmann area 9 middle temporal gyrus
Top expressed in left lobe of liver lumbar subsegment of spinal cord visual cortex cerebellar cortex anterior horn of spinal cord primary visual cortex facial motor nucleus superior frontal gyrus embryo neural layer of retina
More reference expression data
BioGPS
Gene ontology Molecular function
hydrolase activity
protein binding
glutaminase activity
Cellular component
mitochondrial matrix
mitochondrion
Biological process
regulation of apoptotic process
glutamate secretion
cellular amino acid metabolic process
glutamine metabolic process
cellular amino acid biosynthetic process
glutamate biosynthetic process
glutamine catabolic process
reactive oxygen species metabolic process
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001280796 NM_001280797 NM_001280798 NM_013267 NM_138566
NM_001033264 NM_001285777 NM_001285779
RefSeq (protein) NP_001267725 NP_001267726 NP_001267727 NP_037399
NP_001028436 NP_001272706 NP_001272708
Location (UCSC) Chr 12: 56.47 – 56.49 Mb Chr 10: 128.03 – 128.05 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Glutaminase 2 (liver, mitochondrial) is a protein that in humans is encoded by the GLS2 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000135423 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044005 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: Glutaminase 2 (liver, mitochondrial)".
Last Update: 2022-10-11T13:00:08Z
encoded by the GLS2 gene. The GLS2 gene is on the 12th chromosome in humans, with its specific location being 12q13.3. It contains 19 exons. GLS2 is a part...
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Last Update: 2023-12-02T17:44:04Z
Although both "kidney-type" (GLS1) and "liver-type" (GLS2 ) glutaminases are expressed in brain, GLS2 has been reported to exist only in cellular nuclei...
Word Count : 1128
Last Update: 2024-05-08T17:05:46Z
Reactants Products Enzymes Glutamine + H2O → Glu + NH3 GLS, GLS2 NAcGlu + H2O → Glu + acetate N-Acetyl-glutamate synthase α-Ketoglutarate + NADPH + NH4+...
Word Count : 3213
Last Update: 2023-12-01T19:22:59Z
DZANK; EHMT1; EHMT2; ESPN; FANK1; FEM1A; FEM1B; GABPB2; GIT1; GIT2; GLS; GLS2 ; HACE1; HECTD1; IBTK; ILK; INVS; KIDINS220; KRIT1; LRRK1; MAIL; MIB1; MIB2;...
Word Count : 1393