GFRA1 information

GFRA1
Identifiers
Aliases	GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha 1
External IDs	OMIM: 601496; MGI: 1100842; HomoloGene: 3855; GeneCards: GFRA1; OMA:GFRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	116,273,467 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	58,444,341 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; spinal ganglia; ; pars reticulata; ; parietal pleura; ; corpus epididymis; ; lactiferous duct; ; Pars compacta; ; nipple; ; left uterine tube; ; cardia;
	Top expressed in
	vestibular membrane of cochlear duct; ; habenula; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; left lobe of liver; ; lateral septal nucleus; ; iris; ; medullary collecting duct; ; ciliary body; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; glial cell-derived neurotrophic factor receptor activity; signaling receptor activity;
Cellular component	anchored component of membrane; extracellular exosome; membrane; extrinsic component of membrane; intracellular anatomical structure; plasma membrane; external side of plasma membrane; receptor complex;
Biological process	cell surface receptor signaling pathway; nervous system development; MAPK cascade; glial cell-derived neurotrophic factor receptor signaling pathway; axon guidance; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	2674
	14585
	ENSG00000151892
	ENSMUSG00000025089
	P56159
	P97785
NM_001145453; NM_005264; NM_145793; NM_001348096; NM_001348098;
	NM_001348099
	NM_001285457; NM_010279
NP_001138925; NP_005255; NP_665736; NP_001335025; NP_001335027;
	NP_001335028; NP_001369485; NP_001369486; NP_001369487; NP_001369488; NP_001369489; NP_001369490
	NP_001272386; NP_034409
	Wikidata
View/Edit Human	View/Edit Mouse

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025089 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998). "Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization". Cytogenetics and Cell Genetics. 78 (3–4): 289–90. doi:10.1159/000134674. PMID 9465905.
^ Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (Mar 1998). "Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility". Genomics. 48 (3): 354–62. doi:10.1006/geno.1997.5191. PMID 9545641.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025089 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9465905-5] Gorodinsky A, Zimonjic DB, Popescu NC, Milbrandt J (March 1998). "Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization". Cytogenetics and Cell Genetics. 78 (3–4): 289–90. doi:10.1159/000134674. PMID 9465905.

[pmid9545641-6] Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, Fox GM, Chakravarti A (Mar 1998). "Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility". Genomics. 48 (3): 354–62. doi:10.1006/geno.1997.5191. PMID 9545641.

GFRA1 information

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GFRA1

Renal agenesis

Peritubular myoid cell