GDF1 information

GDF1
Identifiers
Aliases	GDF1, DORV, DTGA3, RAI, growth differentiation factor 1, CHTD6, UOG1, LASS1, CERS1, LAG1
External IDs	OMIM: 602880 MGI: 95683 HomoloGene: 105644 GeneCards: GDF1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,896,158 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,784,237 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; superior frontal gyrus; ; ganglionic eminence; ; skeletal muscle tissue; ; prefrontal cortex; ; sensory nervous system; ; sensory organ; ; face; ; Brodmann area 9; ; gastrocnemius muscle;
	Top expressed in
	superior frontal gyrus; ; adrenal gland; ; notochord; ; cerebellar cortex; ; urinary bladder; ; yolk sac; ; white adipose tissue; ; ganglionic eminence; ; limb; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of apoptotic process; positive regulation of pathway-restricted SMAD protein phosphorylation; regulation of MAPK cascade; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2657
	14559
	ENSG00000130283
	ENSMUSG00000109523
	P27539
	P20863
	NM_001492; NM_001387438
	NM_001163282; NM_008107
	NP_001483
	NP_001156754; NP_032133
	Wikidata
View/Edit Human	View/Edit Mouse

Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.^[5]

GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.^[6] It is found in the brain, spinal cord and peripheral nerves of embryos.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109523 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. Bibcode:1991PNAS...88.4250L. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.
^ ^a ^b Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179. S2CID 6787053.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130283 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000109523 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lee_1991-5] Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. Bibcode:1991PNAS...88.4250L. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.

[Rankin_2000-6] Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179. S2CID 6787053.

GDF1 information

and 9 Related for: GDF1 information

GDF1

Paracrine signaling

Transforming growth factor beta superfamily

TGF beta signaling pathway

GDF3

Ceramide synthase 1

Growth differentiation factor

List of OMIM disorder codes

PITX2