clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
synapse
inhibitory synapse
synaptic vesicle membrane
axon
cell junction
perinuclear region of cytoplasm
anchored component of membrane
presynaptic membrane
cytoplasmic vesicle
Biological process
carboxylic acid metabolic process
neurotransmitter biosynthetic process
glutamate decarboxylation to succinate
chemical synaptic transmission
neurotransmitter secretion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2572
14417
Ensembl
ENSG00000136750
ENSMUSG00000026787
UniProt
Q05329
P48320
RefSeq (mRNA)
NM_001134366 NM_000818
NM_008078
RefSeq (protein)
NP_000809 NP_001127838
NP_032104
Location (UCSC)
Chr 10: 26.22 – 26.3 Mb
Chr 2: 22.51 – 22.58 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene.[5]
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff-person syndrome.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000136750 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026787 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cram DS, Barnett LD, Joseph JL, Harrison LC (July 1991). "Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets". Biochem. Biophys. Res. Commun. 176 (3): 1239–44. doi:10.1016/0006-291X(91)90418-7. PMID 2039509.
Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene. This gene encodes one of several forms of glutamic acid decarboxylase...
which are encoded by two different genes on different chromosomes (GAD1 and GAD2 genes, chromosomes 2 and 10 in humans, respectively). GAD67 and GAD65 are...
may have reached lengths of 6–8 m (19.7–26.2 ft). The type specimen MNN GAD2 consists of a maxilla, frontals and a prefrontal, teeth, as well as parietal...
a role in the regulation of Rapid eye movement sleep. Activation of the GAD2 expressing sub-population of the IPN produced the physical symptoms of nicotine...
form and a less-frequent 25-kD form. GAD1 has been shown to interact with GAD2. Glutamate decarboxylase GRCh38: Ensembl release 89: ENSG00000128683 – Ensembl...