Appearance of the cornea by slit-lamp biomicroscopy (left image) and by confocal microscopy (right image) (Courtesy Dr. Charles N. McGhee)
Specialty
Ophthalmology
Fleck corneal dystrophy, also known as Francois-Neetens speckled corneal dystrophy, is a rare form of corneal dystrophy. It is caused by mutations in PIKFYVE gene. Small opacities, some of which resemble "flecks", are scattered in the stroma of the patients. Other opacities look more like snowflakes or clouds. The disease is non-progressive and in most cases asymptomatic, with mild photophobia reported by some patients. In a single case report, a corneal transplantation was performed for concurrent keratoconus, and at 10 years follow-up there was still no evidence of the inclusions in the stroma.[1]
Cornealdystrophy is a group of rare hereditary disorders characterised by bilateral abnormal deposition of substances in the transparent front part of...
refer to: Fibrocystic disease Fleckcornealdystrophy Focal cortical dysplasia Food composition data Fuchs' cornealdystrophy Family Computer Disk System...
alleles are found in 8 out of 10 families with Francois-Neetens cornealfleckdystrophy. Disruption of both PIKFYVE alleles in the mouse is lethal at the...
association with lenticonus posterior. Cataract, flecked retinopathy, posterior polymorphous dystrophy and corneal arcus juvenilis may be encountered in association...
problems; two common ophthalmic conditions in beagles are glaucoma and cornealdystrophy. "Cherry eye", a prolapse of the gland of the third eyelid, and distichiasis...
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