Possible earliest ancestor of the LUCA ancestral cell
The first universal common ancestor (FUCA) is a proposed non-cellular entity that is the earliest ancestor of the last universal common ancestor (LUCA) and its descendants, including every modern cell.[1][2] FUCA would also be the ancestor of ancient sister lineages of LUCA, none of which have modern descendants.[2]
FUCA is thought to have been composed of progenotes, proposed ancient biological systems that would have used RNA for their genome and self-replication, in place of DNA.[3][4][5] By comparison, LUCA would have had a complex metabolism and genome with hundreds of genes and gene families.[1]
The now-extinct sister lineages descended from FUCA are thought to have horizontally transferred some of their genes into the genome of early descendants of LUCA.[2]
^ abProsdocimi, Francisco; José, Marco V.; de Farias, Sávio Torres (2019), Pontarotti, Pierre (ed.), "The First Universal Common Ancestor (FUCA) as the Earliest Ancestor of LUCA's (Last UCA) Lineage", Evolution, Origin of Life, Concepts and Methods, Cham: Springer International Publishing, pp. 43–54, doi:10.1007/978-3-030-30363-1_3, ISBN 978-3-030-30363-1, S2CID 199534387, archived from the original on 2022-06-29, retrieved 2023-11-02
^ abcHarris, Hugh M. B.; Hill, Colin (2021). "A Place for Viruses on the Tree of Life". Frontiers in Microbiology. 11. doi:10.3389/fmicb.2020.604048. ISSN 1664-302X. PMC 7840587. PMID 33519747.
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