FYB information

FYB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RI9, 2GTJ, 2GTO
Identifiers
Aliases	FYB1, ADAP, PRO0823, SLAP-130, SLAP130, FYB, FYN binding protein, THC3, FYN binding protein 1
External IDs	OMIM: 602731; MGI: 1346327; HomoloGene: 22664; GeneCards: FYB1; OMA:FYB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	39,274,528 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	6,692,794 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; bone marrow cells; ; trabecular bone; ; appendix; ; granulocyte; ; spleen; ; epithelium of colon; ; epithelium of nasopharynx;
	Top expressed in
	granulocyte; ; thymus; ; spleen; ; lymph node; ; spermatid; ; mesenteric lymph nodes; ; blood; ; stroma of bone marrow; ; tibiofemoral joint; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; lipid binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; nucleus; actin cytoskeleton; plasma membrane; cell junction;
Biological process	protein phosphorylation; intracellular signal transduction; protein localization to plasma membrane; T cell receptor signaling pathway; immune response; signal transduction; NLS-bearing protein import into nucleus; biological process; integrin-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2533
	23880
	ENSG00000082074
	ENSMUSG00000022148
	O15117
	O35601
	NM_001243093; NM_001465; NM_199335; NM_001349333; NM_018594
	NM_001278269; NM_011815
	NP_001230022; NP_001456; NP_955367; NP_001336262; NP_061064
	NP_001265198; NP_035945
	Wikidata
View/Edit Human	View/Edit Mouse

FYN binding protein (FYB-120/130), also known as FYB, ADAP (Adhesion and degranulation-promoting adapter protein), and SLAP-130 (SLP-76-associated phosphoprotein) is a protein that is encoded by the FYB gene in humans.^[5] The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells.^[6]^[7]^[8]^[9] FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.^[7]^[8]^[9]^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082074 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FYB FYN binding protein (FYB-120/130)".
^ Schraven B, Marie-Cardine A, Koretzky G (June 1997). "Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling". Immunology Letters. 57 (1–3): 165–169. doi:10.1016/s0165-2478(97)00053-9. PMID 9232446.
^ ^a ^b Griffiths EK, Penninger JM (June 2002). "Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap". Current Opinion in Immunology. 14 (3): 317–322. doi:10.1016/s0952-7915(02)00334-5. PMID 11973129.
^ ^a ^b Wang H, Rudd CE (October 2008). "SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion". Trends in Cell Biology. 18 (10): 486–493. doi:10.1016/j.tcb.2008.07.005. PMC 3512129. PMID 18760924.
^ ^a ^b Gerbec ZJ, Thakar MS, Malarkannan S (2015-09-16). "The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells". Frontiers in Immunology. 6: 472. doi:10.3389/fimmu.2015.00472. PMC 4584950. PMID 26441977.
^ Zhang Y, Wang H (April 2012). "Integrin signalling and function in immune cells". Immunology. 135 (4): 268–275. doi:10.1111/j.1365-2567.2011.03549.x. PMC 3372743. PMID 22211918.
^ Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, Kliche S (2021-07-06). "The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events". Frontiers in Immunology. 12: 703534. doi:10.3389/fimmu.2021.703534. PMC 8290198. PMID 34295339.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082074 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FYB FYN binding protein (FYB-120/130)".

[6] Schraven B, Marie-Cardine A, Koretzky G (June 1997). "Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling". Immunology Letters. 57 (1–3): 165–169. doi:10.1016/s0165-2478(97)00053-9. PMID 9232446.

[:0-7] Griffiths EK, Penninger JM (June 2002). "Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap". Current Opinion in Immunology. 14 (3): 317–322. doi:10.1016/s0952-7915(02)00334-5. PMID 11973129.

[:1-8] Wang H, Rudd CE (October 2008). "SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion". Trends in Cell Biology. 18 (10): 486–493. doi:10.1016/j.tcb.2008.07.005. PMC 3512129. PMID 18760924.

[:2-9] Gerbec ZJ, Thakar MS, Malarkannan S (2015-09-16). "The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells". Frontiers in Immunology. 6: 472. doi:10.3389/fimmu.2015.00472. PMC 4584950. PMID 26441977.

[:3-10] Zhang Y, Wang H (April 2012). "Integrin signalling and function in immune cells". Immunology. 135 (4): 268–275. doi:10.1111/j.1365-2567.2011.03549.x. PMC 3372743. PMID 22211918.

[:4-11] Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, Kliche S (2021-07-06). "The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events". Frontiers in Immunology. 12: 703534. doi:10.3389/fimmu.2021.703534. PMC 8290198. PMID 34295339.

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