FBLIM1 information

FBLIM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K9U, 2W0P, 4P3W
Identifiers
Aliases	FBLIM1, CAL, FBLP-1, FBLP1, filamin binding LIM protein 1
External IDs	OMIM: 607747; MGI: 1921452; HomoloGene: 56774; GeneCards: FBLIM1; OMA:FBLIM1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	15,786,594 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,333,407 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; mucosa of ileum; ; popliteal artery; ; tibial arteries; ; cardiac muscle tissue of right atrium; ; saphenous vein; ; pancreatic ductal cell; ; left coronary artery;
	Top expressed in
	interventricular septum; ; ascending aorta; ; tunica media of zone of aorta; ; aortic valve; ; myocardium of ventricle; ; right ventricle; ; genital tubercle; ; cardiac muscles; ; epithelium of stomach; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	filamin binding; protein binding; metal ion binding;
Cellular component	cytoplasm; cytosol; cell cortex; cytoskeleton; stress fiber; focal adhesion; fibrillar center; cell junction;
Biological process	regulation of integrin activation; cell adhesion; cell junction assembly; regulation of cell shape; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54751
	74202
	ENSG00000162458
	ENSMUSG00000006219
	Q8WUP2
	Q71FD7
	NM_001024215; NM_001024216; NM_017556; NM_001350151
	NM_001163256; NM_133754; NM_001378958; NM_001378959
	NP_001019386; NP_001019387; NP_060026; NP_001337080
NP_001156728; NP_598515; NP_001365887; NP_001365888; NP_001391569;
	NP_001391570; NP_001391571; NP_001391572; NP_001391573
	Wikidata
View/Edit Human	View/Edit Mouse

Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.^[5]^[6]^[7]

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162458 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006219 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. S2CID 15051526.
^ Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS (March 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J Biol Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242.
^ ^a ^b "Entrez Gene: FBLIM1 filamin binding LIM protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162458 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006219 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679033-5] Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. S2CID 15051526.

[pmid12496242-6] Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS (March 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J Biol Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242.

[entrez-7] "Entrez Gene: FBLIM1 filamin binding LIM protein 1".

FBLIM1 information

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