FAM86B1 information

FAM86B1
Identifiers
Aliases	FAM86B1, family with sequence similarity 86 member B1
External IDs	OMIM: 616122; MGI: 1917761; GeneCards: FAM86B1; OMA:FAM86B1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	12,194,133 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	5,073,847 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; nucleus accumbens; ; right hemisphere of cerebellum; ; caudate nucleus; ; right frontal lobe; ; hypothalamus; ; putamen; ; left ovary;
	Top expressed in
	interventricular septum; ; right kidney; ; spermatocyte; ; blastocyst; ; morula; ; neural layer of retina; ; proximal tubule; ; yolk sac; ; lip; ; muscle of thigh;
	More reference expression data
	n/a
Orthologs
	85002
	70511
	ENSG00000186523
	ENSMUSG00000022544
	Q8N7N1
	Q3UZW7
	NM_001083537
	NM_027446
	NP_001077006
	NP_081722
	Wikidata
View/Edit Human	View/Edit Mouse

FAM86B1 is a protein, which in humans is encoded by the FAM86B1 gene. FAM86B1 is an essential gene in humans.^[11] The protein contains two domains: FAM86, and AdoMet-MTase.

FAM86B1 homologs are found in most eukaryotes, from mammals to plants such as wild soybean.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186523 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022544 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2023-12-07.
^ Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al. (August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. Bibcode:2021Natur.596..583J. doi:10.1038/s41586-021-03819-2. PMC 8371605. PMID 34265844.
^ Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, et al. (January 2022). "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models". Nucleic Acids Research. Volume 50, Issue D1. 50 (D1): D439–D444. doi:10.1093/nar/gkab1061. PMC 8728224. PMID 34791371.
^ "iCn3D: Web-based 3D Structure Viewer". structure.ncbi.nlm.nih.gov. Retrieved 2023-12-15.
^ Wang J, Youkharibache P, Zhang D, Lanczycki CJ, Geer RC, Madej T, et al. (January 2020). "iCn3D, a web-based 3D viewer for sharing 1D/2D/3D representations of biomolecular structures". Bioinformatics. 36 (1): 131–135. doi:10.1093/bioinformatics/btz502. PMC 6956771. PMID 31218344.
^ Wang J, Youkharibache P, Marchler-Bauer A, Lanczycki C, Zhang D, Lu S, et al. (2022). "iCn3D: From Web-Based 3D Viewer to Structural Analysis Tool in Batch Mode". Frontiers in Molecular Biosciences. 9: 831740. doi:10.3389/fmolb.2022.831740. PMC 8892267. PMID 35252351.
^ Francis JW, Shao Z, Narkhede P, Trinh AT, Lu J, Song J, et al. (July 2023). "The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation". The Journal of Biological Chemistry. 299 (7). Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology: 104842. doi:10.1016/j.jbc.2023.104842. PMC 10285254. PMID 37209825.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186523 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022544 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2023-12-07.

[6] Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al. (August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. Bibcode:2021Natur.596..583J. doi:10.1038/s41586-021-03819-2. PMC 8371605. PMID 34265844.

[7] Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, et al. (January 2022). "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models". Nucleic Acids Research. Volume 50, Issue D1. 50 (D1): D439–D444. doi:10.1093/nar/gkab1061. PMC 8728224. PMID 34791371.

[8] "iCn3D: Web-based 3D Structure Viewer". structure.ncbi.nlm.nih.gov. Retrieved 2023-12-15.

[9] Wang J, Youkharibache P, Zhang D, Lanczycki CJ, Geer RC, Madej T, et al. (January 2020). "iCn3D, a web-based 3D viewer for sharing 1D/2D/3D representations of biomolecular structures". Bioinformatics. 36 (1): 131–135. doi:10.1093/bioinformatics/btz502. PMC 6956771. PMID 31218344.

[10] Wang J, Youkharibache P, Marchler-Bauer A, Lanczycki C, Zhang D, Lu S, et al. (2022). "iCn3D: From Web-Based 3D Viewer to Structural Analysis Tool in Batch Mode". Frontiers in Molecular Biosciences. 9: 831740. doi:10.3389/fmolb.2022.831740. PMC 8892267. PMID 35252351.

[11] Francis JW, Shao Z, Narkhede P, Trinh AT, Lu J, Song J, et al. (July 2023). "The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation". The Journal of Biological Chemistry. 299 (7). Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology: 104842. doi:10.1016/j.jbc.2023.104842. PMC 10285254. PMID 37209825.