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Eyeblink conditioning (EBC) is a form of classical conditioning that has been used extensively to study neural structures and mechanisms that underlie learning and memory. The procedure is relatively simple and usually consists of pairing an auditory or visual stimulus (the conditioned stimulus (CS)) with an eyeblink-eliciting unconditioned stimulus (US) (e.g. a mild puff of air to the cornea or a mild shock). Naïve organisms initially produce a reflexive, unconditioned response (UR) (e.g. blink or extension of nictitating membrane) that follows US onset. After many CS-US pairings, an association is formed such that a learned blink, or conditioned response (CR), occurs and precedes US onset.[1] The magnitude of learning is generally gauged by the percentage of all paired CS-US trials that result in a CR. Under optimal conditions, well-trained animals produce a high percentage of CRs (> 90%). The conditions necessary for, and the physiological mechanisms that govern, eyeblink CR learning have been studied across many mammalian species, including mice, rats, guinea pigs, rabbits, ferrets, cats, and humans. Historically, rabbits have been the most popular research subjects.
^Bracha, Vlastislav (September 1, 2009). "The cerebellum and eyeblink conditioning: learning vs. network performance hypotheses". Neuroscience. 3 (162): 787–96. doi:10.1016/j.neuroscience.2008.12.042. PMC 2822538. PMID 19162131.
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the food, and the conditioned stimulus, the bell, is considered the ISI. More particularly, ISI is often used in eyeblinkconditioning (a widely studied...
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