Global InformationEscherichia coli NC101 information
| Escherichia coli NC101 O2:H6/41 | |
|---|---|
Scientific classification
| |
| Domain: | Bacteria |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Enterobacterales |
| Family: | Enterobacteriaceae |
| Genus: | Escherichia |
| Species: | E. coli |
| Serotype: | E. c. NC101 |
| Trionomial name | |
| Escherichia coli NC101 | |
Escherichia coli (AIEC) NC101 is a mouse isolate, serotype O2:H6/41, that is pro-carcinogenic, adherent-invasive (AIEC), probiotic strain of Escherichia coli, a species of bacteria that thrives in the intestines of mammals.[1][2] NC101 has also been identified as a nicotinic acid (NA) auxotroph, a pathobiont, which is an organism that is harmful under certain circumstances,[3] and is an important, relevant model organism that demonstrates how susceptible individuals may produce inappropriate immune responses to seemingly benign intestinal E. coli.[4]
- ^ Sadecki, Patric W.; Balboa, Samantha J.; Lopez, Lacey R.; Kedziora, Katarzyna M.; Arthur, Janelle C.; Hicks, Leslie M. (2021-07-16). "Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli". ACS Chemical Biology. 16 (7): 1243–1254. doi:10.1021/acschembio.1c00322. ISSN 1554-8929. PMC 8601121. PMID 34232632.
- ^ García, Alexis; Mannion, Anthony; Feng, Yan; Madden, Carolyn M.; Bakthavatchalu, Vasudevan; Shen, Zeli; Ge, Zhongming; Fox, James G. (December 2016). "Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice". Microbes and Infection. 18 (12): 777–786. doi:10.1016/j.micinf.2016.07.005. hdl:1721.1/117656. ISSN 1286-4579. PMC 5182106. PMID 27480057.
- ^ Jochum, Lara; Stecher, Bärbel (2020-10-01). "Label or Concept – What Is a Pathobiont?". Trends in Microbiology. 28 (10): 789–792. doi:10.1016/j.tim.2020.04.011. ISSN 0966-842X. PMID 32376073. S2CID 218532205.
- ^ Lopez, Lacey R.; Barlogio, Cassandra J.; Broberg, Christopher A.; Wang, Jeremy; Arthur, Janelle C. (2021). "A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101". Frontiers in Microbiology. 12: 1081. doi:10.3389/fmicb.2021.670005. ISSN 1664-302X. PMC 8207962. PMID 34149655.