Global InformationEosinophilic cystitis information
| Eosinophilic cystitis | |
|---|---|
| Other names | EoC, EC |
 | |
| Eosinophilic cystitis showing edematous and chronically inflamed lamina propria with numerous eosinophils. | |
| Specialty | Urology |
Eosinophilic cystitis is a rare type of interstitial cystitis first reported in 1960 by Edwin Brown.[1] Eosinophilic cystitis has been linked to a number of etiological factors, including allergies, bladder tumors, trauma to the bladder, parasitic infections, and chemotherapy drugs, though the exact cause of the condition is still unknown. The antigen-antibody response is most likely the cause of eosinophilic cystitis. This results in the generation of different immunoglobulins, which activate eosinophils and start the inflammatory process.[2]
The most typical symptom complex includes dysuria, hematuria, frequency, and suprapubic pain. For diagnosis, cystoscopy and biopsy are considered the gold standard. Peripheral eosinophilia, which is rare in patients, microscopic hematuria, proteinuria, and other laboratory findings corroborate the diagnosis.[2]
Treatment for eosinophilic cystitis is still up for debate. Antihistamines, antispasmodics, leukotriene antagonists, immunosuppressives, oral and intravesical corticosteroids, and in extreme situations, surgery have all been used in the treatment of symptoms.[3]
- ^ Brown, Edwin W. (1960). "Eosinophilic Granuloma of the Bladder". Journal of Urology. 83 (5). Ovid Technologies (Wolters Kluwer Health): 665–668. doi:10.1016/s0022-5347(17)65773-2. ISSN 0022-5347.
- ^ a b Cite error: The named reference
its managementwas invoked but never defined (see the help page). - ^ Cooke, W Donald; Cooke, Abigail J Tarr (2020). "Successful treatment of eosinophilic cystitis with benralizumab". Urology Case Reports. 33. Elsevier BV: 101379. doi:10.1016/j.eucr.2020.101379. ISSN 2214-4420. PMC 7574143. PMID 33102077.