Global InformationEnzybiotics information
Enzybiotics are an experimental antibacterial therapy.[1] The term is derived from a combination of the words “enzyme” and “antibiotics.” Enzymes have been extensively utilized for their antibacterial and antimicrobial properties.[2] Proteolytic enzymes called endolysins have demonstrated particular effectiveness in combating a range of bacteria and are the basis for enzybiotic research.[3] Endolysins are derived from bacteriophages and are highly efficient at lysing bacterial cells.[1][3] Enzybiotics are being researched largely to address the issue of antibiotic resistance, which has allowed for the proliferation of drug-resistant pathogens posing great risk to animal and human health across the globe.[3]
- ^ a b Nelson D, Loomis L, Fischetti VA (March 2001). "Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme". Proceedings of the National Academy of Sciences of the United States of America. 98 (7): 4107–12. Bibcode:2001PNAS...98.4107N. doi:10.1073/pnas.061038398. PMC 31187. PMID 11259652.
- ^ Thallinger B, Prasetyo EN, Nyanhongo GS, Guebitz GM (January 2013). "Antimicrobial enzymes: an emerging strategy to fight microbes and microbial biofilms". Biotechnology Journal. 8 (1): 97–109. doi:10.1002/biot.201200313. PMID 23281326. S2CID 5209651.
- ^ a b c Dams D, Briers Y (2019). "Enzybiotics: Enzyme-Based Antibacterials as Therapeutics". Therapeutic Enzymes: Function and Clinical Implications. Advances in Experimental Medicine and Biology. Vol. 1148. Singapore: Springer Singapore. pp. 233–253. doi:10.1007/978-981-13-7709-9_11. ISBN 978-981-13-7708-2. PMID 31482502. S2CID 201832287.