Global InformationEnzootic nasal tumor virus information
| Enzootic nasal tumor virus | |
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| Ewe infected with enzootic nasal tumor virus. | |
Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Pararnavirae |
| Phylum: | Artverviricota |
| Class: | Revtraviricetes |
| Order: | Ortervirales |
| Family: | Retroviridae |
| Genus: | Betaretrovirus |
| Virus: | Enzootic nasal tumor virus
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The enzootic nasal tumor virus of the betaretrovirus genus is a carcinogenic retrovirus that causes enzootic nasal adenocarcinoma in sheep and goats.[1] Strain ENTV-1 is found in sheep and strain ENTV-2 is found in goats.[2][3] The virus causes tumor growth in the upper nasal cavity and is closely related to JSRV which also causes respiratory tumors in ovine.[4] The disease, enzootic nasal adenocarcinoma is common in North America and is found in sheep and goats on every continent except New Zealand and Australia.[5] There are more than 27 betaretroviruses similar to ENVT and JSRV in the ovine genome.[6][7] In the future, research on ENTV may become important in studying viruses that cause human lung cancer.[8]
- ^ Yu DL, Linnerth-Petrik NM, Halbert CL, Walsh SR, Miller AD, Wootton SK (August 2011). "Jaagsiekte sheep retrovirus and enzootic nasal tumor virus promoters drive gene expression in all airway epithelial cells of mice but only induce tumors in the alveolar region of the lungs". Journal of Virology. 85 (15): 7535–45. doi:10.1128/JVI.00400-11. PMC 3147915. PMID 21593165.
- ^ Cousens C, Minguijon E, Dalziel RG, Ortin A, Garcia M, Park J, Gonzalez L, Sharp JM, de las Heras M. Complete Sequence of Enzootic Nasal Tumor Virus, a Retrovirus Associated with Transmissible Intranasal Tumors of Sheep. American Society for Microbiology. OCLC 679408708.
- ^ Ortín A, Cousens C, Minguijón E, Pascual Z, Villarreal MP, Sharp JM, Heras M (August 2003). "Characterization of enzootic nasal tumour virus of goats: complete sequence and tissue distribution". The Journal of General Virology. 84 (Pt 8): 2245–52. doi:10.1099/vir.0.19125-0. PMID 12867657.
- ^ He Y, Zhang Q, Wang J, Zhou M, Fu M, Xu X (July 2017). "Full-length genome sequence analysis of enzootic nasal tumor virus isolated from goats in China". Virology Journal. 14 (1): 141. doi:10.1186/s12985-017-0795-4. PMC 5530571. PMID 28747230.
- ^ Walsh SR, Linnerth-Petrik NM, Laporte AN, Menzies PI, Foster RA, Wootton SK (July 2010). "Full-length genome sequence analysis of enzootic nasal tumor virus reveals an unusually high degree of genetic stability". Virus Research. 151 (1): 74–87. doi:10.1016/j.virusres.2010.04.002. PMID 20398709.
- ^ De las Heras M, Ortín A, Cousens C, Minguijón E, Sharp JM (2003). "Enzootic Nasal Adenocarcinoma of Sheep and Goats". Jaagsiekte Sheep Retrovirus and Lung Cancer. Current Topics in Microbiology and Immunology. Vol. 275. Springer Berlin Heidelberg. pp. 201–23. doi:10.1007/978-3-642-55638-8_8. ISBN 978-3-642-62897-9. PMID 12596900.
- ^ Rosales Gerpe MC, van Lieshout LP, Domm JM, Ingrao JC, Datu J, Walsh SR, et al. (November 2019). "The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism". Viruses. 11 (11): 1061. doi:10.3390/v11111061. PMC 6893448. PMID 31739606.
- ^ Dirks C, Duh FM, Rai SK, Lerman MI, Miller AD (March 2002). "Mechanism of cell entry and transformation by enzootic nasal tumor virus". Journal of Virology. 76 (5): 2141–9. doi:10.1128/jvi.76.5.2141-2149.2002. PMC 153819. PMID 11836391.