EMX1 information

EMX1
Identifiers
Aliases	EMX1, empty spiracles homeobox 1
External IDs	OMIM: 600034; MGI: 95387; HomoloGene: 55799; GeneCards: EMX1; OMA:EMX1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	72,936,071 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	85,181,444 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; oocyte; ; gonad; ; right frontal lobe; ; human kidney; ; Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	ventricular zone; ; Subplate; ; primary visual cortex; ; right kidney; ; superior frontal gyrus; ; otic vesicle; ; dentate gyrus of hippocampal formation granule cell; ; renal cortex; ; human kidney; ; proximal tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; nucleolus;
Biological process	regulation of transcription, DNA-templated; homeostasis of number of cells; cerebral cortex regionalization; in utero embryonic development; post-embryonic development; neuron projection extension; neuroepithelial cell differentiation; radial glial cell differentiation; multicellular organism development; regulation of oligodendrocyte progenitor proliferation; telencephalon development; brain development; neuron differentiation; cerebral cortex development; cerebral cortex neuron differentiation; brain morphogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2016
	13796
	ENSG00000135638
	ENSMUSG00000033726
	Q04741
	Q04742
	NM_001040404; NM_004097
	NM_010131
	NP_004088
	NP_034261
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein EMX1 is a protein that in humans is encoded by the EMX1 gene.^[5]^[6] The transcribed EMX1 gene is a member of the EMX family of transcription factors. The EMX1 gene, along with its family members, are expressed in the developing cerebrum (also known as the telencephalon).^[7] EMX1 plays a role in specification of positional identity, the proliferation of neural stem cells, differentiation of layer-specific neuronal phenotypes and commitment to a neuronal or glial cell fate.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135638 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.
^ "Entrez Gene: EMX1 empty spiracles homeobox 1".
^ Cecchi C, Boncinelli E (August 2000). "Emx homeogenes and mouse brain development". Trends Neurosci. 23 (8): 347–52. doi:10.1016/S0166-2236(00)01608-8. PMID 10906797. S2CID 45006292.
^ Schuurmans C, Guillemot F (February 2002). "Molecular mechanisms underlying cell fate specification in the developing telencephalon". Curr. Opin. Neurobiol. 12 (1): 26–34. doi:10.1016/S0959-4388(02)00286-6. PMID 11861161. S2CID 27988180.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135638 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033726 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959790-5] Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.

[entrez-6] "Entrez Gene: EMX1 empty spiracles homeobox 1".

[Cecchi_2000-7] Cecchi C, Boncinelli E (August 2000). "Emx homeogenes and mouse brain development". Trends Neurosci. 23 (8): 347–52. doi:10.1016/S0166-2236(00)01608-8. PMID 10906797. S2CID 45006292.

[Schuurmans_2002-8] Schuurmans C, Guillemot F (February 2002). "Molecular mechanisms underlying cell fate specification in the developing telencephalon". Curr. Opin. Neurobiol. 12 (1): 26–34. doi:10.1016/S0959-4388(02)00286-6. PMID 11861161. S2CID 27988180.

EMX1 information

and 9 Related for: EMX1 information

EMX1

Cerebral cortex

List of human transcription factors

Electribe

Homeobox

EMX homeogene

EMX

Cerebral organoid

EMX2