adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
84658
n/a
Ensembl
ENSG00000131355
n/a
UniProt
Q9BY15
n/a
RefSeq (mRNA)
NM_001289158 NM_001289159 NM_032571 NM_152939
n/a
RefSeq (protein)
NP_001276087 NP_001276088 NP_115960
n/a
Location (UCSC)
Chr 19: 14.62 – 14.69 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[3][4] EMR3 is a member of the adhesion GPCR family.[5][6]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[7]
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[8] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[9] Mice, next to Emr2, lack the Emr3 gene.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000131355 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
^Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056. S2CID 37679823.
^Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
^Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal. 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. S2CID 16254868.
mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized...
gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19. Like the related CD97 protein, the fourth EGF-like domain...