EMILIN1 information

EMILIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KA3, 2OII
Identifiers
Aliases	EMILIN1, EMI, EMILIN, gp115, elastin microfibril interfacer 1
External IDs	OMIM: 130660; MGI: 1926189; HomoloGene: 5117; GeneCards: EMILIN1; OMA:EMILIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,086,403 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,078,621 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; left uterine tube; ; ascending aorta; ; left coronary artery; ; stromal cell of endometrium; ; canal of the cervix; ; popliteal artery; ; gastric mucosa; ; upper lobe of left lung; ; myometrium;
	Top expressed in
	glomerulus; ; glomerular basement membrane; ; yolk sac; ; calvaria; ; serosa of urinary bladder; ; molar; ; placenta; ; lamina propria of urinary bladder; ; lip; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; extracellular matrix constituent conferring elasticity; identical protein binding; integrin binding involved in cell-matrix adhesion; extracellular matrix structural constituent;
Cellular component	collagen; extracellular region; extracellular exosome; extracellular space; extracellular matrix; integrin alpha4-beta1 complex; EMILIN complex; collagen-containing extracellular matrix;
Biological process	cell adhesion; cell-matrix adhesion; cell migration; protein homotrimerization; aortic valve morphogenesis; positive regulation of gene expression; negative regulation of gene expression; positive regulation of cell-substrate adhesion; negative regulation of angiogenesis; extracellular matrix organization; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of collagen biosynthetic process; elastic fiber assembly; negative regulation of cell activation; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of ERK1 and ERK2 cascade; positive regulation of extracellular matrix assembly; negative regulation of collagen fibril organization; negative regulation of macrophage migration;
	Sources:Amigo / QuickGO
Orthologs
	11117
	100952
	ENSG00000138080
	ENSMUSG00000029163
	Q9Y6C2
	Q99K41
	NM_007046
	NM_133918
	NP_008977
	NP_598679
	Wikidata
View/Edit Human	View/Edit Mouse

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene.^[5] It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138080 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029163 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EMILIN1 elastin microfibril interfacer 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138080 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029163 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EMILIN1 elastin microfibril interfacer 1".

EMILIN1 information

and 3 Related for: EMILIN1 information

EMILIN1

Reticular connective tissue

Emilin