Global InformationDimethylargininase information
| dimethylargininase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Ribbon diagram of human DDAH1.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.3.18 | ||||||||
| CAS no. | 123644-75-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In the field of enzymology, a dimethylargininase, also known as a dimethylarginine dimethylaminohydrolase (DDAH), is an enzyme that catalyzes the chemical reaction:
- N-omega,N-omega'-methyl-L-arginine + H2O dimethylamine + L-citrulline
Thus, the two substrates of this enzyme are N-omega,N-omega'-methyl-L-arginine and H2O, whereas its two products are dimethylamine and L-citrulline.
- ^ PDB: 3I2E; Wang W, Monzingo AF, Hu S, Schaller TH, Robertus JD, Fast W (2009). "Developing Dual and Specific Inhibitors of Dimethylarginine Dimethylaminohydrolase-1 and Nitric Oxide Synthase: Toward a Targeted Polypharmacology To Control Nitric Oxide". Biochemistry. 48 (36): 8624–8635. doi:10.1021/bi9007098. PMC 2746464. PMID 19663506.; rendered via PyMOL.