Example of breast constituents' concentrations maps through optical mammography (right cranio-caudal view). The blue arrow points to the lesion. Hb stands for deoxy-hemoglobin, HbO2 for oxy-hemoglobin, tHb for total hemoglobin.[1]
Purpose
investigation of the breast composition through spectral analysis
Diffuse optical mammography, or simply optical mammography, is an emerging imaging technique that enables the investigation of the breast composition through spectral analysis. It combines in a single non-invasive tool the capability to implement breast cancer risk assessment,[2] lesion characterization,[3] therapy monitoring[4] and prediction of therapy outcome.[5] It is an application of diffuse optics, which studies light propagation in strongly diffusive media, such as biological tissues, working in the red and near-infrared spectral range, between 600 and 1100 nm.[6]
^Cite error: The named reference Taroni-2017 was invoked but never defined (see the help page).
^Taroni, Paola; Pifferi, Antonio; Quarto, Giovanna; Spinelli, Lorenzo; Torricelli, Alessandro; Abbate, Francesca; Villa, Anna; Balestreri, Nicola; Menna, Simona; Cassano, Enrico; Cubeddu, Rinaldo (2010). "Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy". Journal of Biomedical Optics. 15 (6): 060501–060501–3. Bibcode:2010JBO....15f0501T. doi:10.1117/1.3506043. PMID 21198142.
^Quarto, Giovanna; Spinelli, Lorenzo; Pifferi, Antonio; Torricelli, Alessandro; Cubeddu, Rinaldo; Abbate, Francesca; Balestreri, Nicola; Menna, Simona; Cassano, Enrico; Taroni, Paola (18 September 2014). "Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography". Biomedical Optics Express. 5 (10): 3684–3698. doi:10.1364/BOE.5.003684. PMC 4206334. PMID 25360382.
^Jiang, Shudong; Pogue, Brian W.; Carpenter, Colin M.; Poplack, Steven P.; Wells, Wendy A.; Kogel, Christine A.; Forero, Jorge A.; Muffly, Lori S.; Schwartz, Gary N.; Paulsen, Keith D.; Kaufman, Peter A. (August 2009). "Evaluation of Breast Tumor Response to Neoadjuvant Chemotherapy with Tomographic Diffuse Optical Spectroscopy: Case Studies of Tumor Region-of-Interest Changes". Radiology. 252 (2): 551–560. doi:10.1148/radiol.2522081202. PMC 2753781. PMID 19508985.
^Cerussi, A.; Hsiang, D.; Shah, N.; Mehta, R.; Durkin, A.; Butler, J.; Tromberg, B. J. (28 February 2007). "Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy". Proceedings of the National Academy of Sciences. 104 (10): 4014–4019. Bibcode:2007PNAS..104.4014C. doi:10.1073/pnas.0611058104. PMC 1805697. PMID 17360469.
^Martelli, Fabrizio; Del Bianco, Samuele; Ismaelli, Andrea; Zaccanti, Giovanni (2010). Light propagation through biological tissue and other diffusive media : theory, solutions, and software. SPIE. ISBN 9780819476586.
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