A dicentric chromosome is an abnormal chromosome with two centromeres. It is formed through the fusion of two chromosome segments, each with a centromere, resulting in the loss of acentric fragments (lacking a centromere) and the formation of dicentric fragments.[1] The formation of dicentric chromosomes has been attributed to genetic processes, such as Robertsonian translocation[1] and paracentric inversion.[2] Dicentric chromosomes have important roles in the mitotic stability of chromosomes and the formation of pseudodicentric chromosomes.[1][3] Their existence has been linked to certain natural phenomena such as irradiation and have been documented to underlie certain clinical syndromes, notably Kabuki syndrome.[3][4] The formation of dicentric chromosomes and their implications on centromere function are studied in certain clinical cytogenetics laboratories.[5]
^ abcNussbaum, Robert; McInnes, Roderick; Willard, Huntington; Hamosh, Ada (2007). Thompson & Thompson Genetics in Medicine. Philadelphia(PA): Saunders. p. 72. ISBN 978-1-4160-3080-5.
^Hartwell, Leland; Hood, Leeroy; Goldberg, Michael; Reynolds, Ann; Lee, Silver (2011). Genetics From Genes to Genomes, 4e. New York: McGraw-Hill. ISBN 9780073525266.
^ abLynch, Sally; et al. (1995). "Kabuki syndrome-like features in monozygotic twin boys with a pseudodicentric chromosome 13". J. Med. Genet. 32 (32:227–230): 227–230. doi:10.1136/jmg.32.3.227. PMC 1050324. PMID 7783176.
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and 26 Related for: Dicentric chromosome information
A dicentricchromosome is an abnormal chromosome with two centromeres. It is formed through the fusion of two chromosome segments, each with a centromere...
occur. Chromosome-breaking events can also generate acentric chromosomes or acentric fragments. A dicentricchromosome is an abnormal chromosome with...
together to form one dicentricchromosome, and then segregate into two different nuclei. Because pulling the dicentricchromosome apart causes a double...
also produce monocentric isochromosomes, but they are not as common as dicentric isochromosomes. A more common mechanism in the formation of isochromosomes...
the dicentric recombinant generates dicentric bridges as it is pulled in two directions. In a pericentric inversion, similar imbalanced chromosomes are...
is the possibility of producing a dicentricchromosome – a chromosome with two centromeres. When dicentricchromosomes form, a series of events can occur...
in dicentricchromosomes that detach from the spindle during anaphase. Micronuclei originating from chromosome loss events and acentric chromosome fragments...
to activate the SAC: spindle depolymerization, the presence of dicentricchromosomes (with two centromeres), centromeres segregating in an aberrant way...
following table summarizes symbols and abbreviations used in cytogenetics: Chromosome abnormalities Directionality (molecular biology) for 3' and 5' notation...
two copies of others. The process can also lead to dicentric or acentric chromosomes (chromosomes with two centromeres or no centromere), which are inherently...
to end fusion and the formation of anaphase bridges resulting in dicentricchromosomes that can result in further rearrangements. This is a more plausible...
(1 July 2017). "Centromere Destiny in DicentricChromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region". Molecular...
called a dicentricchromosome. The tetrasomy can also be formed independently of cell division. Double stranded breaks in the short arm of chromosome 9 may...
analyzing dicentricchromosomes after acute radiation exposure. Dicentricchromosomes result from defective repair of chromosome breaks in two chromosomes, resulting...
result in dicentricchromosomes lead to chromosome breakage during anaphase. This further contributes to gene loss on duplicated chromosomes. The duplicated...
to the formation of a dicentricchromosome and an acentric fragment. The acentric fragment is frequently lost, while the dicentric fragment forms a bridge...
also called marker chromosome 15 syndrome, idic(15), partial tetrasomy 15q, or inverted duplication 15 (inv dup 15), is a chromosome abnormality in which...
regulated by the cell cycle and proteolysis. DicentricchromosomeChromosomal rearrangement Chromosomal inversion CENPA Satellite DNA Fukagawa, Tatsuo;...
control mechanism localize specifically to the active centromere on dicentricchromosomes". Human Genetics. 107 (4): 376–384. doi:10.1007/s004390000386. PMID 11129339...
control mechanism localize specifically to the active centromere on dicentricchromosomes". Human Genetics. 107 (4): 376–84. doi:10.1007/s004390000386. PMID 11129339...
centromeric cytogenetic damages, and higher frequencies of chromosomal translocations, rings and dicentrics. Other analyses have shown persistent depression of...
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