Dendrodendritic synapses are connections between the dendrites of two different neurons. This is in contrast to the more common axodendritic synapse (chemical synapse) where the axon sends signals and the dendrite receives them. Dendrodendritic synapses are activated in a similar fashion to axodendritic synapses in respects to using a chemical synapse. An incoming action potential permits the release of neurotransmitters to propagate the signal to the post synaptic cell. There is evidence that these synapses are bi-directional, in that either dendrite can signal at that synapse. Ordinarily, one of the dendrites will display inhibitory effects while the other will display excitatory effects.[1] The actual signaling mechanism utilizes Na+ and Ca2+ pumps in a similar manner to those found in axodendritic synapses.[2]
^Shepherd, G.M. (1996). "The dendritic spine: a multifunctional integrative unit". J. Neurophysiol. 75 (6): 2197–2210. doi:10.1152/jn.1996.75.6.2197. PMID 8793734.
^Masurkar, Arjun; Chen, Wei (Jan 25, 2012). "The influence of single bursts versus single spikes at excitatory dendrodendritic synapses". European Journal of Neuroscience. 35 (3): 389–401. doi:10.1111/j.1460-9568.2011.07978.x. PMC 4472665. PMID 22277089.
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