Datumetine is a tropane alkaloid found in leaves of Datura metel.[1] It is said to modulate NMDA receptor and thus causes memory loss.[2] It also causes epileptic seizures in mice.[2] Docking studies suggest that it fits on both allosteric and orthosteric sites of NMDA receptor.[2] It acts together with other anticholinergic tropane alkaloids of datura to cause amnesia.[citation needed]
^Siddiqui S, Sultana N, Ahmed SS, Haider SI (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products. 49 (3): 511–513. doi:10.1021/np50045a023. ISSN 0163-3864.
^ abcIshola AO, Imam A, Ajao MS (2021). "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports. 8: 1131–1142. doi:10.1016/j.toxrep.2021.05.009. PMC 8190477. PMID 34150523.
Datumetine is a tropane alkaloid found in leaves of Datura metel. It is said to modulate NMDA receptor and thus causes memory loss. It also causes epileptic...
highly poisonous tropane alkaloids meteloidine and its angelate ester and datumetine and may be fatal if ingested by humans or other animals, including livestock...
C16H21NO3 (molar mass: 275.35 g/mol, exact mass: 275.1521 u) may refer to: Datumetine Homatropine Methylenedioxypyrovalerone (MDPV) Rolipram This set index...