Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.[5][6]
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.[6] A relatively specific inhibitor of DPP8 and DPP9, Val-boroPro [7]-,[8] leads to increased activation of the inflammasome though both NLRBP1 and CARD8 and can trigger pyroptosis.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000074603 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032393 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem. 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666.
^ ab"Entrez Gene: DPP8 dipeptidyl-peptidase 8".
^"PubChem:Val-boroPro".
^Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA (March 2018). "Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome". Cell Chemical Biology. 25 (3): 262–267.e5. doi:10.1016/j.chembiol.2017.12.013. PMC 5856610. PMID 29396289.
^Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA (August 2018). "DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia". Nature Medicine. 24 (8): 1151–1156. doi:10.1038/s41591-018-0082-y. PMC 6082709. PMID 29967349.
Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene. This gene encodes a member of the peptidase S9B family, a small family...
potential for the treatment of diabetes. More recently his work has shown that DPP8/9 inhibitors trigger an immune response. He also designed, synthesized, and...
and APAF1. Via its FIIND domain, NLRP1 interacts directly with DPP9 and DPP8 which are needed to prevent NLRP1 activation. Loss of DPP9 in humans and...