DIO2 information

DIO2
Identifiers
Aliases	DIO2, 5DII, D2, DIOII, SelY, TXDI2, deiodinase, iodothyronine, type II, iodothyronine deiodinase 2, SELENOY
External IDs	OMIM: 601413; MGI: 1338833; HomoloGene: 621; GeneCards: DIO2; OMA:DIO2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	80,387,757 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	90,705,212 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; tendon of biceps brachii; ; body of tongue; ; superior surface of tongue; ; oral cavity; ; thyroid gland; ; right lobe of thyroid gland; ; nipple; ; human penis; ; left lobe of thyroid gland;
	Top expressed in
	median eminence; ; cervix; ; ascending aorta; ; ligament; ; Region I of hippocampus proper; ; arcuate nucleus; ; lumbar subsegment of spinal cord; ; aortic valve; ; spiral ligament; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; selenium binding; thyroxine 5'-deiodinase activity; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	thyroid hormone metabolic process; thyroid hormone generation; selenocysteine incorporation; hormone biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1734
	13371
	ENSG00000211448
	ENSMUSG00000007682
	Q92813
	Q9Z1Y9
NM_013989; NM_000793; NM_001007023; NM_001242503; NM_001324462;
	NM_001366496
	NM_010050
	NP_000784; NP_001311391; NP_054644; NP_001353425
	NP_034180
	Wikidata
View/Edit Human	View/Edit Mouse

Type II iodothyronine deiodinase (iodothyronine 5'-deiodinase, iodothyronine 5'-monodeiodinase) is an enzyme that in humans is encoded by the DIO2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000211448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007682 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Croteau W, Davey JC, Galton VA, St Germain DL (Sep 1996). "Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues". J Clin Invest. 98 (2): 405–417. doi:10.1172/JCI118806. PMC 507444. PMID 8755651.
^ Araki O, Murakami M, Morimura T, Kamiya Y, Hosoi Y, Kato Y, Mori M (Jun 1999). "Assignment of type II iodothyronine deiodinase gene (DIO2) to human chromosome band 14q24.2→q24.3 by in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 73–74. doi:10.1159/000015218. PMID 10343107. S2CID 19715942.
^ "Entrez Gene: DIO2 deiodinase, iodothyronine, type II".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000211448 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007682 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8755651-5] Croteau W, Davey JC, Galton VA, St Germain DL (Sep 1996). "Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues". J Clin Invest. 98 (2): 405–417. doi:10.1172/JCI118806. PMC 507444. PMID 8755651.

[pmid10343107-6] Araki O, Murakami M, Morimura T, Kamiya Y, Hosoi Y, Kato Y, Mori M (Jun 1999). "Assignment of type II iodothyronine deiodinase gene (DIO2) to human chromosome band 14q24.2→q24.3 by in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 73–74. doi:10.1159/000015218. PMID 10343107. S2CID 19715942.

[entrez-7] "Entrez Gene: DIO2 deiodinase, iodothyronine, type II".

DIO2 information

and 9 Related for: DIO2 information

DIO2

Deiodinase

Proopiomelanocortin

GPIB

Selenoprotein

Iodothyronine deiodinase

D2

Makossa

USP33