dentate gyrus of hippocampal formation granule cell
lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
nucleotide binding
helicase activity
protein binding
nucleic acid binding
hydrolase activity
ATP binding
RNA binding
Cellular component
catalytic step 2 spliceosome
U5 snRNP
nucleoplasm
spliceosomal complex
extracellular exosome
nucleus
nucleolus
cytoplasm
Biological process
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
mRNA processing
RNA secondary structure unwinding
RNA splicing
cis assembly of pre-catalytic spliceosome
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9416
74351
Ensembl
ENSG00000174243
ENSMUSG00000003360
UniProt
Q9BUQ8
n/a
RefSeq (mRNA)
NM_004818
NM_001080981
RefSeq (protein)
NP_004809
n/a
Location (UCSC)
Chr 12: 48.83 – 48.85 Mb
Chr 15: 98.54 – 98.56 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.[5][6][7]
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000174243 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000003360 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Teigelkamp S, Mundt C, Achsel T, Will CL, Luhrmann R (Jan 1998). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p". RNA. 3 (11): 1313–26. PMC 1369570. PMID 9409622.
^Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711.
^ ab"Entrez Gene: DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23".
Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene. This gene encodes a member of the DEAD box protein...