porphyrin-containing compound biosynthetic process
response to iron ion
heme biosynthetic process
response to lead ion
response to inorganic substance
response to insecticide
response to methylmercury
protoporphyrinogen IX biosynthetic process from glutamate
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1371
12892
Ensembl
n/a
ENSMUSG00000022742
UniProt
P36551
P36552
RefSeq (mRNA)
NM_000097
NM_007757
RefSeq (protein)
NP_000088
NP_031783
Location (UCSC)
n/a
Chr 16: 58.49 – 58.54 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Coprogen oxidase
coproporphyrinogen iii oxidase from leishmania major
Identifiers
Symbol
Coprogen oxidase
Pfam
PF01218
InterPro
IPR001260
PROSITE
PDOC00783
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Coproporphyrinogen-III oxidase, mitochondrial (abbreviated as CPOX) is an enzyme that in humans is encoded by the CPOX gene.[4][5][6] A genetic defect in the enzyme results in a reduced production of heme in animals. The medical condition associated with this enzyme defect is called hereditary coproporphyria.[7][8]
CPOX, the sixth enzyme of the haem biosynthetic pathway, converts coproporphyrinogen III to protoporphyrinogen IX through two sequential steps of oxidative decarboxylation.[9] The activity of the CPOX enzyme, located in the mitochondrial membrane, is measured in lymphocytes.[10]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022742 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lamoril J, Martasek P, Deybach JC, Da Silva V, Grandchamp B, Nordmann Y (February 1995). "A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria". Human Molecular Genetics. 4 (2): 275–8. doi:10.1093/hmg/4.2.275. PMID 7757079.
^Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S (October 1993). "Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation". The Journal of Biological Chemistry. 268 (28): 21359–63. doi:10.1016/S0021-9258(19)36931-5. PMID 8407975.
^"Entrez Gene: CPOX coproporphyrinogen oxidase".
^"Hereditary coproporphyria". Genetic and Rare Diseases Information Center. National Institutes of Health. Archived from the original on 7 August 2012. Retrieved 8 August 2011.
^"CPOX". Genetics Home Reference. Retrieved 8 August 2011.
^Sano S, Granick S (April 1961). "Mitochondrial coproporphyrinogen oxidase and protoporphyrin formation". The Journal of Biological Chemistry. 236 (4): 1173–80. doi:10.1016/S0021-9258(18)64262-0. PMID 13746277.
^Guo R, Lim CK, Peters TJ (October 1988). "Accurate and specific HPLC assay of coproporphyrinogen III oxidase activity in human peripheral leucocytes". Clinica Chimica Acta; International Journal of Clinical Chemistry. 177 (3): 245–52. doi:10.1016/0009-8981(88)90069-1. PMID 3233772.
and 18 Related for: Coproporphyrinogen III oxidase information
Coproporphyrinogen-IIIoxidase, mitochondrial (abbreviated as CPOX) is an enzyme that in humans is encoded by the CPOX gene. A genetic defect in the enzyme...
carbon dioxide molecules. CoproporphyrinogenIII is further used as a substrate for the enzyme coproporphyrinogenIIIoxidase which oxidizes and further...
include oxygen-independent coproporphyrinogen-IIIoxidase, HemF, HemN, radical SAM enzyme, and coproporphyrinogenIIIoxidase. This enzyme participates...
Hereditary coproporphyria, which is characterized by a deficiency in coproporphyrinogenoxidase, coded for by the CPOX gene, may also present with both acute...
uroporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase, and it is converted into protoporphyrinogen IX by coproporphyrinogenIIIoxidase. Coproporphyrinogens...
which is hydrolysed to form the circular tetrapyrrole uroporphyrinogen III. This molecule undergoes a number of further modifications. Intermediates...
or anaerobic coproporphyrinogenIIIoxidase is a radical SAM enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogenIII to protoporhyrinogen...
CPOX may refer to: CoproporphyrinogenIIIoxidase Catalytic partial oxidation This disambiguation page lists articles associated with the title CPOX. If...
Class C methylase has homologous sequence with the RS enzyme, coproporphyrinogenIIIoxidase (HemN), which also catalyzes the methylation of sp2-hybridized...
hepatic porphyria. HCP is caused by a deficiency of the enzyme coproporphyrinogenoxidase, coded for by the CPOX gene, and is inherited in an autosomal...
compound is synthesized in most organisms from coproporphyrinogenIII by the enzyme coproporphyrinogenoxidase: The process entails conversion of two of four...
in the methylene bridges). Uroporphyrinogen III, precursor to coproporphyrinogenIII. coproporphyrinogenIII, precursor to protoporphyrinogen IX. Protoporphyrinogen...
other porphyria. Enzyme tests show markedly reduced activity of coproporphyrinogenoxidase, compared to both unaffected individuals and those affected with...
O, Sandal L, Sandal NN, Marcker KA (October 1993). "A soybean coproporphyrinogenoxidase gene is highly expressed in root nodules". Plant Molecular Biology...
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