Constructive neutral evolution(CNE) is a theory that seeks to explain how complex systems can evolve through neutral transitions and spread through a population by chance fixation (genetic drift).[1] Constructive neutral evolution is a competitor for both adaptationist explanations for the emergence of complex traits and hypotheses positing that a complex trait emerged as a response to a deleterious development in an organism.[2] Constructive neutral evolution often leads to irreversible or "irremediable" complexity[3] and produces systems which, instead of being finely adapted for performing a task, represent an excess complexity that has been described with terms such as "runaway bureaucracy" or even a "Rube Goldberg machine".[4]
The groundworks for the concept of CNE were laid by two papers in the 1990s, although first explicitly proposed by Arlin Stoltzfus in 1999.[1][2][5] The first proposals for the role CNE was in the evolutionary origins of complex macromolecular machines such as the spliceosome, RNA editing machinery, supernumerary ribosomal proteins, chaperones, and more.[4][6][7] Since then and as an emerging trend of studies in molecular evolution,[8] CNE has been applied to broader features of biology and evolutionary history including some models of eukaryogenesis, the emergence of complex interdependence in microbial communities, and de novo formation of functional elements from non-functional transcripts of junk DNA.[9][10] Several approaches propose a combination of neutral and adaptive contributions in the evolutionary origins of various traits.[11]
Many evolutionary biologists posit that CNE must be the null hypothesis when explaining the emergence of complex systems to avoid assuming that a trait arose for an adaptive benefit. A trait may have arisen neutrally, even if later co-opted for another function. This approach stresses the need for rigorous demonstrations of adaptive explanations when describing the emergence of traits. This avoids the "adaptationist fallacy" which assumes that all traits emerge because they are adaptively favoured by natural selection.[9][12]
^ abStoltzfus, Arlin (1999). "On the Possibility of Constructive Neutral Evolution". Journal of Molecular Evolution. 49 (2): 169–181. Bibcode:1999JMolE..49..169S. doi:10.1007/PL00006540. ISSN 0022-2844. PMID 10441669. S2CID 1743092.
^Gray, Michael W.; Lukeš, Julius; Archibald, John M.; Keeling, Patrick J.; Doolittle, W. Ford (2010-11-12). "Irremediable Complexity?". Science. 330 (6006): 920–921. Bibcode:2010Sci...330..920G. doi:10.1126/science.1198594. ISSN 0036-8075. PMID 21071654. S2CID 206530279.
^ abLukeš, Julius; Archibald, John M.; Keeling, Patrick J.; Doolittle, W. Ford; Gray, Michael W. (2011). "How a neutral evolutionary ratchet can build cellular complexity". IUBMB Life. 63 (7): 528–537. doi:10.1002/iub.489. PMID 21698757. S2CID 7306575.
^Covello, PatrickS.; Gray, MichaelW. (1993). "On the evolution of RNA editing". Trends in Genetics. 9 (8): 265–268. doi:10.1016/0168-9525(93)90011-6. PMID 8379005.
^Gray, Michael W.; Lukeš, Julius; Archibald, John M.; Keeling, Patrick J.; Doolittle, W. Ford (2010-11-12). "Irremediable Complexity?". Science. 330 (6006): 920–921. Bibcode:2010Sci...330..920G. doi:10.1126/science.1198594. ISSN 0036-8075. PMID 21071654. S2CID 206530279.
^Lamech, Lilian T.; Mallam, Anna L.; Lambowitz, Alan M. (2014-12-23). Herschlag, Daniel (ed.). "Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases". PLOS Biology. 12 (12): e1002028. doi:10.1371/journal.pbio.1002028. ISSN 1545-7885. PMC 4275181. PMID 25536042.
^Liberles, David A.; Chang, Belinda; Geiler-Samerotte, Kerry; Goldman, Aaron; Hey, Jody; Kaçar, Betül; Meyer, Michelle; Murphy, William; Posada, David; Storfer, Andrew (2020). "Emerging Frontiers in the Study of Molecular Evolution". Journal of Molecular Evolution. 88 (3): 211–226. Bibcode:2020JMolE..88..211L. doi:10.1007/s00239-020-09932-6. ISSN 0022-2844. PMC 7386396. PMID 32060574.
^ abCite error: The named reference :3 was invoked but never defined (see the help page).
^Palazzo, Alexander F.; Koonin, Eugene V. (2020-11-25). "Functional Long Non-coding RNAs Evolve from Junk Transcripts". Cell. 183 (5): 1151–1161. doi:10.1016/j.cell.2020.09.047. PMID 33068526. S2CID 222815635.
^Vosseberg, Julian; Snel, Berend (2017-12-01). "Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery". Biology Direct. 12 (1): 30. doi:10.1186/s13062-017-0201-6. ISSN 1745-6150. PMC 5709842. PMID 29191215.
^Cite error: The named reference :2 was invoked but never defined (see the help page).
and 28 Related for: Constructive neutral evolution information
Constructiveneutralevolution (CNE) is a theory that seeks to explain how complex systems can evolve through neutral transitions and spread through a...
The neutral theory of molecular evolution holds that most evolutionary changes occur at the molecular level, and most of the variation within and between...
and thus provide evidence for evolution of functional proteins from non-functional sequences. Constructiveneutralevolution (CNE) explains that complex...
the complexity of an organism increases by a process called constructiveneutralevolution. Since the effective population size in eukaryotes (especially...
on neutral mutations. In the 1990s, constructiveneutralevolution was proposed which seeks to explain how complex systems emerge through neutral transitions...
exploitation, a type of military computer network operation Constructiveneutralevolution Contrat nouvelle embauche, a type of employment contract Corpo...
stochastic forces in evolution, such as genetic hitchhiking, also known as genetic draft. Another concept is constructiveneutralevolution (CNE), which explains...
cite neutralevolution as the null hypothesis in evolutionary studies, i.e., offering a direct contrast to the adaptationist approach. Constructive neutral...
the lenses of constructiveneutralevolution. Constructiveneutralevolution seeks to explain how complex systems can emerge through neutral transitions...
introduction of variation Coalescent theory Conservation genetics Constructiveneutralevolution Directional selection Distribution of fitness effects (DFE)...
separate functions. Subfunctionalization is a neutral mutation process of constructiveneutralevolution; meaning that no new adaptations are formed. During...
complemented by the other copy. This leads to a neutral "subfunctionalization" (a process of constructiveneutralevolution) or DDC (duplication-degeneration-complementation)...
Stoltzfus A (August 1999). "On the possibility of constructiveneutralevolution". Journal of Molecular Evolution. 49 (2): 169–181. Bibcode:1999JMolE..49..169S...
Berning, Daniel J.; Gross, Joshua B. (2020-02-06). "Parallel evolution of regressive and constructive craniofacial traits across distinct populations of Astyanax...
Constructive engagement was the name given to the conciliatory foreign policy of the Reagan administration towards the apartheid regime in South Africa...
The constructive developmental framework (CDF) is a theoretical framework for epistemological and psychological assessment of adults. The framework is...
setting forth the laws; 3.the return to God in the Hereafter, and the constructive role of this belief in the course of man's ascent towards God; 4.the...
Watts, Fraser; Turner, Léon P. (eds.). Evolution, Religion, and Cognitive Science: Critical and Constructive Essays. Oxford: Oxford University Press...
as constructive changes. This shows that both selection and evolution have a role in advancing reductive changes (e.g smaller eyes) and constructive changes...
claiming that matter and mind are one thing, [panpsychism] has little constructive to say and offers no positive laws explaining how the mind is organized...
up into four types of learning activities which are passive, active, constructive, and interactive. It is shown that students will gain more knowledge...
achieving some measure of peace as a by-product of a lifestyle they feel is constructive and healthy". When the same members attended an appearance by Prem Rawat...
greatest biologist since Darwin": Not only was he the most original and constructive of the architects of the neo-Darwinian synthesis, Fisher also was the...
Turner, Scott (2014). "The role of internal and external constructive processes in evolution". Journal of Physiology. 592 (11): 2413–2422. doi:10.1113/jphysiol...
represents the horizontal axis, while the center of the circle represents a neutral valence and a medium level of arousal. In this model, emotional states...
cultural, and social evolution. Drawing on theories from critical posthumanism and transhumanism, the journal encourages constructive and critical dialogue...
scientific knowledge and the design and use of technologies. The co-constructive relationship between gender and technology contributed to feminist STS's...
consider preferential allocation of surplus food supplies to states deemed constructive in use of population control measures. The paper takes a look at worldwide...
Global Information