Combinatorial ablation and immunotherapy information
Combinatorial ablation and immunotherapy
Specialty
oncology
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Combinatorial ablation and immunotherapy is an oncological treatment that combines various tumor-ablation techniques with immunotherapy treatment.[1][2][3][4] Combining ablation therapy of tumors with immunotherapy enhances the immunostimulating response and has synergistic effects for curative metastatic cancer treatment.[2][3] Various ablative techniques are utilized including cryoablation, radiofrequency ablation, laser ablation, photodynamic ablation, stereotactic radiation therapy, alpha-emitting radiation therapy, hyperthermia therapy, HIFU.[5][6][7][8][9] Thus, combinatorial ablation of tumors and immunotherapy is a way of achieving an autologous, in-vivo tumor lysate vaccine and treating metastatic disease.
^Dupuy; et al. (2014). "Thermal ablation of tumours: biological mechanisms and advances in therapy". Nature Reviews Cancer. 14 (3): 199–208. doi:10.1038/nrc3672. PMID 24561446. S2CID 9224039.
^ abMehta, Amol; Oklu, Rahmi; Sheth, Rahul A. (2015). "Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?". Gastroenterology Research and Practice. 2016: 1–11. doi:10.1155/2016/9251375. PMC 4802022. PMID 27051417.
^ ab"Immunotherapy could transform systemic power of locoregional IO treatments". 2016. Archived from the original on 2020-12-01. Retrieved 2017-05-03.
^Dranoff, Glenn (2016). Cancer Immunology and Immunotherapy. Springer. p. 218. ISBN 9783642141362. Archived from the original on 2021-03-17. Retrieved 2021-10-18.
^Prof. Yona Keisari. "Development of Cancer Treatments Integrating Radiotherapy or Electrochemical Ablation and Immunotherapy". Archived from the original on 2018-03-17. Retrieved 2017-05-03.
^Ito, A; Tanaka, K; Kondo, K; Shinkai, M; Honda, H; Matsumoto, K; Saida, T; Kobayashi, T (2003). "Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma". Cancer Science. 94 (3): 308–13. doi:10.1111/j.1349-7006.2003.tb01438.x. PMC 11160160. PMID 12824927.
^Xiaoming Yang (2016). "Radiofrequency hyperthermia promotes the therapeutic effects on chemotherapeutic-resistant breast cancer when combined with heat shock protein promoter-controlled HSV-TK gene therapy: Toward imaging-guided interventional gene therapy". Oncotarget. 7 (40): 65042–65051. doi:10.18632/oncotarget.11346. PMC 5323137. PMID 27542255.
^Braiden, V; Ohtsuru, A; Kawashita, Y; Miki, F; Sawada, T; Ito, M; Cao, Y; Kaneda, Y; Koji, T; Yamashita, S (2000). "Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter". Human Gene Therapy. 11 (18): 2453–63. doi:10.1089/10430340050207948. PMID 11119417.
^Takeda, Tsutomu; Takeda, Takashi (2016). "Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia". Hyperthermic Oncology from Bench to Bedside. pp. 319–327. doi:10.1007/978-981-10-0719-4_30. ISBN 978-981-10-0717-0.
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