Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.[1]
Its water-soluble hydrochloride salt (NKH 477)[2] is an adenylyl cyclase activator which has been studied for its cardiac selectivity.[3][4]
^"colforsin daropate". ChEBI. EMBL-EBI. Retrieved 6 January 2022.
^"β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1)". CAS Common Chemistry. American Chemical Society. Retrieved 6 January 2022.
^Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M (August 1994). "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". J. Cardiovasc. Pharmacol. 24 (2): 310–6. doi:10.1097/00005344-199424020-00018. PMID 7526066.
^Sanbe A, Takeo S (July 1995). "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". J. Pharmacol. Exp. Ther. 274 (1): 120–6. PMID 7616388.
Colforsindaropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine. Its water-soluble hydrochloride...
pathways such as protein kinase A and EPAC1. Its derivatives include colforsindaropate, NKH477, and FSK88, which may be more potent than forskolin at raising...