Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane
CAS Number
26658-42-4N 37296-80-3 (HCl)
PubChem CID
62816
DrugBank
DB00375Y
ChemSpider
none
UNII
K50N755924
KEGG
C06925Y
ChEMBL
ChEMBL1201678Y
CompTox Dashboard (EPA)
DTXSID00965206 DTXSID901009549, DTXSID00965206
ECHA InfoCard
100.123.044
Chemical and physical data
Formula
(C4H10N3)m(C3H6O)n
NY (what is this?)(verify)
Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL).[1][2] It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.[3]
Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.[4]
^Handelsman Y (May 2011). "Role of bile acid sequestrants in the treatment of type 2 diabetes". Diabetes Care. 34 (Suppl 2): S244-50. doi:10.2337/dc11-s237. PMC 3632187. PMID 21525463.
^"Colestipol Hydrochloride". Drugs.com.
^"colestipol (Colestid)". MedicineNet.
^Mutschler E, Schäfer-Korting M (2001). Arzneimittelwirkungen (in German) (8th ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 523. ISBN 3-8047-1763-2.
Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL)....
the principal therapy for bile acid-induced diarrhea. Cholestyramine, colestipol and colesevelam have all been used. Doses may not need to be as high as...
This can be treated with a bile acid sequestrant like cholestyramine, colestipol or colesevelam, which may be better tolerated. Symptoms of postcholecystectomy...
magnesium-containing antacids, simethicone, sucralfate, cholestyramine, colestipol, and polystyrene sulfonate. Sevelamer with calcium carbonate may decrease...
need therapy modifications: Bile acid sequestrants (e.g. cholestyramine, colestipol, etc.): If taken together, bile acid resins may bind to fenofibrate, resulting...
decreased by taking concurrent aspirin. Bile acid binding resins, such as colestipol, cholestyramine, and colesevelam, function by binding bile acids, increasing...
main agents used to treat bile acid malabsorption. Cholestyramine and colestipol, both in powder form, have been used for many years. Unfortunately, many...
of pruritus consists of anion-exchange resins, such as cholestyramine, colestipol, or colesevalam. These anion-exchange resins are nonabsorbed, highly positively...
cholesterol to replace lost bile acids. Resins include cholestyramine, colestipol, and colesevalem, and they all decrease LDL-C while increasing HDL-C levels...
drugs is required, such as bile acid sequestrants (cholestyramine or colestipol), nicotinic acid preparations or fibrates. Control of other risk factors...
alone is insufficient, bile acid-binding resins (e.g., cholestyramine, colestipol) could be considered. In October 2002, a new cholesterol absorption inhibitor...
in tablet form in packages containing no more than 84 mg of the drug. Colestipol in powder form in packages containing no more than 5 grams of the drug...
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