Intoxication caused by excessive levels of cobalt in the body
Medical condition
Cobalt poisoning
Cobalt
Specialty
Toxicology
Cobalt poisoning is intoxication caused by excessive levels of cobalt in the body. Cobalt is an essential element for health in animals in minute amounts as a component of vitamin B12. A deficiency of cobalt, which is very rare, is also potentially lethal, leading to pernicious anemia.[1]
Exposure to cobalt metal dust is most common in the fabrication of tungsten carbide.[2] Another source is from wear and tear of certain metal-on-metal hip prostheses.[3]
Per the International Agency for Research on Cancer (IARC), cobalt metal with tungsten carbide is "probably carcinogenic to humans" (IARC Group 2A Agent), whereas cobalt metal without tungsten carbide is "possibly carcinogenic to humans" (IARC Group 2B Agent).
^Cite error: The named reference Ullmann was invoked but never defined (see the help page).
^Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L (15 July 2017). "Cobalt toxicity in humans—A review of the potential sources and systemic health effects". Toxicology. 387: 43–56. doi:10.1016/j.tox.2017.05.015. hdl:10044/1/51711. PMID 28572025.
^Zywiel, MG; Cherian, JJ; Banerjee, S; Cheung, AC; Wong, F; Butany, J; Gilbert, C; Overgaard, C; Syed, K; Jacobs, JJ; Mont, MA (January 2016). "Systemic cobalt toxicity from total hip arthroplasties: review of a rare condition Part 2. measurement, risk factors, and step-wise approach to treatment". The Bone & Joint Journal. 98-B (1): 14–20. doi:10.1302/0301-620X.98B1.36712. PMID 26733510.
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