A chromatography detector is a device that detects and quantifies separated compounds as they elute from the chromatographic column. These detectors are integral to various chromatographic techniques, such as gas chromatography,[1] liquid chromatography, and high-performance liquid chromatography,[2] and supercritical fluid chromatography[3] among others. The main function of a chromatography detector is to translate the physical or chemical properties of the analyte molecules into measurable signal, typically electrical signal, that can be displayed as a function of time in a graphical presentation, called a chromatograms. Chromatograms can provide valuable information about the composition and concentration of the components in the sample.
Detectors operate based on specific principles, including optical, electrochemical, thermal conductivity, fluorescence, mass spectrometry, and more. Each type of detector has its unique capabilities and is suitable for specific applications, depending on the nature of the analytes and the sensitivity and selectivity required for the analysis.
There are two general types of detectors: destructive and non-destructive. The destructive detectors perform continuous transformation of the column effluent (burning, evaporation or mixing with reagents) with subsequent measurement of some physical property of the resulting material (plasma, aerosol or reaction mixture). The non-destructive detectors are directly measuring some property of the column eluent (for example, ultraviolet absorption) and thus affords greater analyte recovery.
^Adlard, E.R.; Juvet, R.S. (January 1975). "A Review of Detectors for Gas Chromatography Part I: Universal Detectors". C R C Critical Reviews in Analytical Chemistry. 5 (1): 03–13. doi:10.1080/10408347508542678. ISSN 0007-8980.
^Swartz, Michael (2010-07-13). "HPLC Detectors: A Brief Review". Journal of Liquid Chromatography & Related Technologies. 33 (9–12): 1130–1150. doi:10.1080/10826076.2010.484356. ISSN 1082-6076. S2CID 39911656.
A chromatographydetector is a device that detects and quantifies separated compounds as they elute from the chromatographic column. These detectors are...
Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without...
ionization detector (FID) is a scientific instrument that measures analytes in a gas stream. It is frequently used as a detector in gas chromatography. The...
light scattering detector (ELSD) is a destructive chromatographydetector, used in conjunction with high-performance liquid chromatography (HPLC), ultra...
An ultraviolet detector (also known as UV detector or UV-Vis detector) is a type of non-destructive chromatographydetector which measures the amount of...
column inlet to the detector) under set conditions. See also: Kovats' retention index Sample – the matter analyzed in chromatography. It may consist of...
Column chromatography in chemistry is a chromatography method used to isolate a single chemical compound from a mixture. Chromatography is able to separate...
detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC)...
Gel permeation chromatography (GPC) is a type of size-exclusion chromatography (SEC), that separates high molecular weight or colloidal analytes on the...
Lovelock and is used in gas chromatography to detect trace amounts of chemical compounds in a sample. The electron capture detector is used for detecting electron-absorbing...
conductivity detector (TCD), also known as a katharometer, is a bulk property detector and a chemical specific detector commonly used in gas chromatography. This...
ionization detector (DID), but uses a different sort of spark Poole, Colin F. (2015-11-20). "Ionization-based detectors for gas chromatography". Journal...
instantaneous readings, operate continuously, and are commonly used as detectors for gas chromatography or as hand-held portable instruments. Hand-held, battery-operated...
Ion chromatography (or ion-exchange chromatography) is a form of chromatography that separates ions and ionizable polar molecules based on their affinity...
sanitation devices Mars solar date Mass spectrometric detector, a type of chromatographydetector Mean squared displacement, a statistical measure of random...
A pulsed discharge ionization detector (pulsed discharge detector) is a detector for gas chromatography that utilizes a stable, low powered, pulsed DC...
research facility in the Netherlands Refractive index detector, a type of chromatographydetector Registry of Interpreters for the Deaf, an American Sign...
for high-performance liquid chromatography and size exclusion chromatography. They are considered to be universal detectors because they can detect anything...
interaction chromatography (or hydrophilic interaction liquid chromatography, HILIC) is a variant of normal phase liquid chromatography that partly overlaps...
A discharge ionization detector (DID) is a type of detector used in gas chromatography. A DID is an ion detector which uses a high-voltage electric discharge...
into the detector. The differences in masses of the fragments allows the mass analyzer to sort the ions by their mass-to-charge ratio. The detector measures...
Global Information