Global InformationCeftaroline fosamil information
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| Trade names | Teflaro, Zinforo |
| Other names | PPI 0903, TAK-599 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a611014 |
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| Routes of administration | Intravenous |
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| Protein binding | 20% |
| Elimination half-life | 2.5 hours |
| Excretion | Urine (88%), faeces (6%) |
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| Formula | C22H21N8O8PS4 |
| Molar mass | 684.67 g·mol−1 |
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Ceftaroline fosamil (INN) /sɛfˈtæroʊliːn/, brand name Teflaro in the US and Zinforo in Europe,[1][2] is a cephalosporin antibiotic with anti-MRSA activity.[3] Ceftaroline fosamil is a prodrug of ceftaroline. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria. It retains some activity of later-generation cephalosporins having broad-spectrum activity against Gram-negative bacteria, but its effectiveness is relatively much weaker.[4][5] It is currently being investigated for community-acquired pneumonia[6] and complicated skin and skin structure infection.[7][8][9]
Ceftaroline is being developed[when?] by Forest Laboratories, under a license from Takeda.[9] Ceftaroline received approval from the U.S. Food and Drug Administration (FDA) for the treatment of community-acquired bacterial pneumonia and acute bacterial skin infections on 29 October 2010.[10] In vitro studies show it has a similar spectrum to ceftobiprole,[not verified in body] the only other fifth-generation cephalosporin to date,[when?] although no head-to-head clinical trials have been conducted. Ceftaroline and ceftobiprole are on an unnamed subclass of cephalosporins by the Clinical and Laboratory Standards Institute (CLSI).[not verified in body]
It was removed from the World Health Organization's List of Essential Medicines in 2019.[11]
- ^ a b "Teflaro- ceftaroline fosamil powder, for solution". DailyMed. 24 September 2019. Retrieved 1 March 2020.
- ^ a b "Zinforo EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 1 March 2020.
- ^ Duplessis C, Crum-Cianflone NF (February 2011). "Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)". Clinical Medicine Reviews in Therapeutics. 3: a2466. doi:10.4137/CMRT.S1637. PMC 3140339. PMID 21785568.
- ^ Karlowsky JA, Adam HJ, Decorby MR, Lagacé-Wiens PR, Hoban DJ, Zhanel GG (June 2011). "In vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in Canadian hospitals in 2009". Antimicrobial Agents and Chemotherapy. 55 (6): 2837–2846. doi:10.1128/aac.01787-10. PMC 3101400. PMID 21402844.
- ^ Flamm RK, Sader HS, Jones RN (October 2010). "Spectrum and potency of ceftaroline against leading pathogens causing community-acquired respiratory tract and skin and soft tissue infections in Latin America, 2010". The Brazilian Journal of Infectious Diseases. 17 (5): 564–572. doi:10.1016/j.bjid.2013.02.008. PMC 9425132. PMID 23916453.
- ^ Cite error: The named reference
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pmid19207097was invoked but never defined (see the help page). - ^ a b Parish D, Scheinfeld N (February 2008). "Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection". Current Opinion in Investigational Drugs. 9 (2): 201–209. PMID 18246523.
- ^ "Forest Announces FDA Approval of Teflaro (ceftaroline fosamil) for the Treatment of Community-Acquired Bacterial Pneumonia and Acute Bacterial Skin and Skin Structure Infection" (Press release). Forest Laboratories. 29 October 2010. Retrieved 30 October 2010.
- ^ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.