Global InformationCanine discoid lupus erythematosus information
Discoid lupus erythematosus (DLE) is an uncommon autoimmune disease of the basal cell layer of the skin. It occurs in humans[1] and cats, more frequently occurring in dogs. It was first described in dogs by Griffin and colleagues in 1979.[2][3] DLE is one form of cutaneous lupus erythematosus (CLE). DLE occurs in dogs in two forms: a classical facial predominant form or generalized with other areas of the body affected. Other non-discoid variants of CLE include vesicular CLE, exfoliative CLE and mucocutaneous CLE.[4] It does not progress to systemic lupus erythematosus (SLE) in dogs. SLE can also have skin symptoms, but it appears that the two are either separate diseases.[5] DLE in dogs differs from SLE in humans in that plasma cells predominate histologically instead of T lymphocytes.[6] Because worsening of symptoms occurs with increased ultraviolet light exposure, sun exposure most likely plays a role in DLE, although certain breeds (see below) are predisposed.[7] After pemphigus foliaceus, DLE is the second most common autoimmune skin disease in dogs.[8]
- ^ American Osteopathic College of Dermatology, "Discoid Lupus Erythematosus".
- ^ Griffin, C.E.; Stannard, A.A.; Ihrke, P.J.; Ardans, A.A.; Cello, R.M.; Bjorling, D.R. (November 1979). "Canine discoid lupus erythematosus". Veterinary Immunology and Immunopathology. 1 (1): 79–87. doi:10.1016/0165-2427(79)90009-6. PMID 15612271.
- ^ Olivry, Thierry; Linder, Keith E.; Banovic, Frane (December 2018). "Cutaneous lupus erythematosus in dogs: a comprehensive review". BMC Veterinary Research. 14 (1): 132. doi:10.1186/s12917-018-1446-8. ISSN 1746-6148. PMC 5907183. PMID 29669547.
- ^ Banovic, Frane (January 2019). "Canine Cutaneous Lupus Erythematosus". Veterinary Clinics of North America: Small Animal Practice. 49 (1): 37–45. doi:10.1016/j.cvsm.2018.08.004. PMID 30227971. S2CID 52295619.
- ^ Ettinger, Stephen J.; Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Company. ISBN 0-7216-6795-3. OCLC 28723106.
- ^ Griffin, Craig E.; Miller, William H.; Scott, Danny W. (2001). Small Animal Dermatology (6th ed.). W.B. Saunders Company. ISBN 0-7216-7618-9. OCLC 43845516.
- ^ Mueller, Ralf S. (2005). "Immune-mediated skin diseases" (PDF). Proceedings of the 50° Congresso Nazionale Multisala SCIVAC. Retrieved 2007-03-13.
- ^ Osborn, S. (2006). "Autoimmune Diseases in the Dog". Proceedings of the North American Veterinary Conference. Retrieved 2007-03-13.