CYTH2 information

CYTH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PBV, 1R8M, 1R8Q, 1R8S, 1S9D, 4JMI, 4JMO, 4JWL, 4JXH, 4L5M, 4Z21
Identifiers
Aliases	CYTH2, ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, cytohesin 2, cytohesin-2
External IDs	OMIM: 602488; MGI: 1334255; HomoloGene: 32116; GeneCards: CYTH2; OMA:CYTH2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,482,314 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,464,005 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; frontal pole; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; Brodmann area 10; ; middle frontal gyrus; ; gallbladder; ; canal of the cervix; ; minor salivary glands; ; skin of abdomen;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; neural tube; ; spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; spermatocyte; ; seminal vesicula; ; visual cortex; ; superior surface of tongue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,4,5 trisphosphate binding; protein binding; guanyl-nucleotide exchange factor activity; lipid binding;
Cellular component	cytoplasm; growth cone; plasma membrane; cell projection; membrane; Golgi membrane; cytosol; adherens junction; bicellular tight junction; cell junction;
Biological process	regulation of ARF protein signal transduction; endocytosis; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	9266
	19158
	ENSG00000105443
	ENSMUSG00000003269
	Q99418
	P63034
	NM_004228; NM_017457
	NM_001112701; NM_011181
	NP_004219; NP_059431
	NP_001106171; NP_035311
	Wikidata
View/Edit Human	View/Edit Mouse

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105443 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003269 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. doi:10.1016/S0092-8674(00)80095-1. PMID 8706128. S2CID 18390795.
^ Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M (1996). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. Bibcode:1996Natur.384..481C. doi:10.1038/384481a0. PMID 8945478. S2CID 4361989.
^ "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105443 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003269 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8706128-5] Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, Stockinger H, Seed B (Sep 1996). "Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule". Cell. 86 (2): 233–42. doi:10.1016/S0092-8674(00)80095-1. PMID 8706128. S2CID 18390795.

[pmid8945478-6] Chardin P, Paris S, Antonny B, Robineau S, Béraud-Dufour S, Jackson CL, Chabre M (1996). "A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains". Nature. 384 (6608): 481–4. Bibcode:1996Natur.384..481C. doi:10.1038/384481a0. PMID 8945478. S2CID 4361989.

[entrez-7] "Entrez Gene: PSCD2 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)".

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