regulation of synaptic vesicle fusion to presynaptic active zone membrane
regulation of neurotransmitter secretion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10814
12890
Ensembl
ENSG00000145920
ENSMUSG00000025867
UniProt
Q6PUV4
P84086
RefSeq (mRNA)
NM_001008220 NM_006650 NM_032282
NM_009946 NM_001362218
RefSeq (protein)
NP_001008221 NP_006641
NP_034076 NP_001349147
Location (UCSC)
Chr 5: 175.8 – 175.88 Mb
Chr 13: 54.52 – 54.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.[5][6][7]
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000145920 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025867 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
^Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
Complexin-2 is a protein that in humans is encoded by the CPLX2 gene. Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that...