positive regulation of protein-containing complex assembly
positive regulation of interleukin-1 beta production
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of phagocytosis
positive regulation of killing of cells of other organism
positive regulation of cytokine production involved in inflammatory response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
64581
56644
Ensembl
ENSG00000172243
ENSMUSG00000079293
UniProt
Q9BXN2
V9GXI5
RefSeq (mRNA)
NM_022570 NM_197947 NM_197948 NM_197949 NM_197950
NM_197951 NM_197952 NM_197953 NM_197954
NM_020008 NM_001309637
RefSeq (protein)
NP_072092 NP_922938 NP_922939 NP_922940 NP_922941
NP_922945
NP_001296566 NP_064392
Location (UCSC)
Chr 12: 10.12 – 10.13 Mb
Chr 6: 129.44 – 129.45 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene.[5] CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000172243 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000079293 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: CLEC7A C-type lectin domain family 7, member A".
member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD)...
connected by β-1,3-glycosidic linkages. It binds to TLR 2 and Dectin-1 (CLEC7A). Zymosan is a ligand found on the surface of fungi, like yeast. Zymosan...
domain family 4 member A. CD368 Also known as CLEC4D. CD369 Also known as CLEC7A. C-type lectin domain family 7 member A or Dectin-1 CD370 Also known as...