CLDN4 information

CLDN4
Identifiers
Aliases	CLDN4, CPE-R, CPER, CPETR, CPETR1, WBSCR8, hCPE-R, claudin 4
External IDs	OMIM: 602909 MGI: 1313314 HomoloGene: 1000 GeneCards: CLDN4
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,832,690 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,975,788 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; skin of abdomen; ; minor salivary glands; ; rectum; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; islet of Langerhans; ; gallbladder; ; mucosa of urinary bladder;
	Top expressed in
	lip; ; corneal stroma; ; saccule; ; otic placode; ; submandibular gland; ; esophagus; ; duodenum; ; blastocyst; ; morula; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; transmembrane signaling receptor activity; identical protein binding; chloride channel activity; protein binding;
Cellular component	integral component of membrane; cell junction; basal plasma membrane; apicolateral plasma membrane; integral component of plasma membrane; apical plasma membrane; lateral plasma membrane; bicellular tight junction; membrane; plasma membrane; chloride channel complex;
Biological process	response to progesterone; female pregnancy; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; circadian rhythm; establishment of skin barrier; signal transduction; chloride transport; renal absorption; chloride transmembrane transport; ion transport;
	Sources:Amigo / QuickGO
Orthologs
	1364
	12740
	ENSG00000189143
	ENSMUSG00000047501
	O14493
	O35054
	NM_001305
	NM_009903
	NP_001296
	NP_034033
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin 4, also known as CLDN4, is a protein which in humans is encoded by the CLDN4 gene. It belongs to the group of claudins.

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.^[5]

Claudin 4 can also be used as a marker for distinguishing malignant mesothelioma from lung cancer and uterine serous carcinoma.^[6] As a pancreatic cancer marker in cell-blocks of effusion specimens, it has also been found to have a superior performance to BerEp4 staining.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189143 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047501 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLDN4 claudin 4".
^ Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma". Int J Surg Pathol. 21 (5): 493–501. doi:10.1177/1066896913491320. PMID 23775021. S2CID 6840615.
^ Vojtek M, Walsh MD, Papadimos DJ, Shield PW (2019). "Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens" (PDF). Cytopathology. 30 (6): 614–619. doi:10.1111/cyt.12765. PMID 31390089. S2CID 199468828.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189143 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047501 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN4 claudin 4".

[pmid23775021-6] Ohta Y, Sasaki Y, Saito M, Kushima M, Takimoto M, Shiokawa A, Ota H (2013). "Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma". Int J Surg Pathol. 21 (5): 493–501. doi:10.1177/1066896913491320. PMID 23775021. S2CID 6840615.

[VojtekWalsh2019-7] Vojtek M, Walsh MD, Papadimos DJ, Shield PW (2019). "Claudin-4 immunohistochemistry is a useful pan-carcinoma marker for serous effusion specimens" (PDF). Cytopathology. 30 (6): 614–619. doi:10.1111/cyt.12765. PMID 31390089. S2CID 199468828.

CLDN4 information

and 4 Related for: CLDN4 information

CLDN4

Williams syndrome

Claudin

DNAJC30