CLDN2 information

CLDN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YYX
Identifiers
Aliases	CLDN2, claudin 2, OAZON
External IDs	OMIM: 300520; MGI: 1276110; HomoloGene: 9621; GeneCards: CLDN2; OMA:CLDN2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	106,930,861 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	138,712,135 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gallbladder; ; islet of Langerhans; ; kidney; ; right lobe of liver; ; seminal vesicula; ; renal cortex; ; renal medulla; ; duodenum; ; caput epididymis;
	Top expressed in
	kidney; ; proximal tubule; ; crypt of lieberkuhn of small intestine; ; left colon; ; yolk sac; ; left lobe of liver; ; duodenum; ; ciliary body; ; ileum; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; structural molecule activity;
Cellular component	cell junction; integral component of membrane; bicellular tight junction; plasma membrane; membrane;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	9075
	12738
	ENSG00000165376
	ENSMUSG00000047230
	P57739
	O88552
	NM_020384; NM_001171092; NM_001171095
	NM_016675
	NP_001164563; NP_001164566; NP_065117
	NP_057884
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.^[5]^[6] It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047230 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morita K, Furuse M, Fujimoto K, Tsukita S (March 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
^ ^a ^b "Entrez Gene: CLDN2 claudin 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165376 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047230 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9892664-5] Morita K, Furuse M, Fujimoto K, Tsukita S (March 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.

[entrez-6] "Entrez Gene: CLDN2 claudin 2".