CACNA1G information

CACNA1G
Identifiers
Aliases	CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G, SCA42ND
External IDs	OMIM: 604065 MGI: 1201678 HomoloGene: 22544 GeneCards: CACNA1G
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,627,474 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,365,024 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; endothelial cell; ; prefrontal cortex; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; postcentral gyrus; ; superior frontal gyrus; ; canal of the cervix; ; Brodmann area 9; ; hypothalamus;
	Top expressed in
	cerebellar cortex; ; medial dorsal nucleus; ; superior frontal gyrus; ; cerebellar vermis; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; superior colliculus; ; subiculum; ; vas deferens; ; cingulate gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium channel activity; scaffold protein binding; voltage-gated ion channel activity; ion channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved SA node cell action potential; low voltage-gated calcium channel activity; voltage-gated sodium channel activity;
Cellular component	integral component of membrane; membrane; voltage-gated calcium channel complex; cytoplasm; plasma membrane;
Biological process	membrane depolarization during action potential; calcium ion import; regulation of membrane potential; regulation of ion transmembrane transport; regulation of atrial cardiac muscle cell membrane depolarization; ion transport; regulation of heart rate; positive regulation of calcium ion-dependent exocytosis; transmembrane transport; action potential; response to nickel cation; calcium ion transport; chemical synaptic transmission; AV node cell to bundle of His cell signaling; regulation of heart rate by cardiac conduction; SA node cell action potential; AV node cell action potential; SA node cell to atrial cardiac muscle cell signaling; membrane depolarization during AV node cell action potential; calcium ion transmembrane transport; membrane depolarization during SA node cell action potential; cardiac muscle cell action potential involved in contraction; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8913
	12291
	ENSG00000006283
	ENSMUSG00000020866
	O43497
	n/a
NM_001256324; NM_001256325; NM_001256326; NM_001256327; NM_001256328;
	NM_001256329; NM_001256330; NM_001256331; NM_001256332; NM_001256333; NM_001256334; NM_001256359; NM_001256360; NM_001256361; NM_018896; NM_198376; NM_198377; NM_198378; NM_198379; NM_198380; NM_198382; NM_198383; NM_198384; NM_198385; NM_198386; NM_198387; NM_198388; NM_198396; NM_198397
	NM_001112813; NM_001177888; NM_001177890; NM_009783
NP_001243253; NP_001243254; NP_001243255; NP_001243256; NP_001243257;
	NP_001243258; NP_001243259; NP_001243260; NP_001243261; NP_001243262; NP_001243263; NP_001243288; NP_001243289; NP_001243290; NP_061496; NP_938190; NP_938191; NP_938192; NP_938193; NP_938194; NP_938196; NP_938197; NP_938198; NP_938199; NP_938200; NP_938201; NP_938202; NP_938406
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca_v3.1 is a protein which in humans is encoded by the CACNA1G gene.^[5]^[6]^[7] It is one of the primary targets in the pharmacology of absence seizure.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
^ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.
^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".

[pmid9495342-6] Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.

[pmid16382099-7] Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

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