C9orf3 information

AOPEP
Identifiers
Aliases	AOPEP, chromosome 9 open reading frame 3, AP-O, APO, C90RF3, ONPEP, aminopeptidase O (putative), C9orf3
External IDs	MGI: 1919311; HomoloGene: 66273; GeneCards: AOPEP; OMA:AOPEP - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	95,087,218 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	63,473,910 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; body of uterus; ; popliteal artery; ; tibial arteries; ; left uterine tube; ; sural nerve; ; left coronary artery;
	Top expressed in
	lip; ; ascending aorta; ; genital tubercle; ; right kidney; ; aortic valve; ; muscle of thigh; ; tail of embryo; ; superior frontal gyrus; ; interventricular septum; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; zinc ion binding; peptidase activity; metallopeptidase activity; hydrolase activity; metal ion binding; metalloaminopeptidase activity; aminopeptidase activity;
Cellular component	cytoplasm; nucleolus; cytosol; nucleus;
Biological process	proteolysis; peptide catabolic process; angiotensin maturation;
	Sources:Amigo / QuickGO
Orthologs
	84909
	72061
	ENSG00000148120
	ENSMUSG00000021458
	Q8N6M6
	Q8BXQ6
	NM_001193329; NM_001193330; NM_001193331; NM_032823
	NM_001289924; NM_001289926; NM_028079
	NP_001180258; NP_001180260; NP_116212
	NP_001276853; NP_001276855
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome 9 open reading frame 3 (C9ORF3) also known as aminopeptidase O (APO) is an enzyme which in humans is encoded by the C9ORF3 gene.^[5] The protein encoded by this gene is an aminopeptidase which is most closely related in sequence to leukotriene A4 hydrolase (LTA4H).^[6] APO is a member of the M1 metalloproteinase family.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148120 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021458 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ Díaz-Perales A, Quesada V, Sánchez LM, Ugalde AP, Suárez MF, Fueyo A, López-Otín C (April 2005). "Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase". J. Biol. Chem. 280 (14): 14310–7. doi:10.1074/jbc.M413222200. PMID 15687497. (Retracted, see doi:10.1074/jbc.w118.007327. If this is an intentional citation to a retracted paper, please replace {{retracted|...}} with {{retracted|...|intentional=yes}}.)
^ Axton R, Wallis JA, Taylor H, Hanks M, Forrester LM (March 2008). "Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology". J. Cell. Biochem. 103 (4): 1171–82. doi:10.1002/jcb.21497. PMID 17803194. S2CID 11365605.
^ Albiston AL, Ye S, Chai SY (October 2004). "Membrane bound members of the M1 family: more than aminopeptidases". Protein Pept. Lett. 11 (5): 491–500. doi:10.2174/0929866043406643. PMID 15544570.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148120 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021458 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[pmid15687497-6] Díaz-Perales A, Quesada V, Sánchez LM, Ugalde AP, Suárez MF, Fueyo A, López-Otín C (April 2005). "Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase". J. Biol. Chem. 280 (14): 14310–7. doi:10.1074/jbc.M413222200. PMID 15687497. (Retracted, see doi:10.1074/jbc.w118.007327. If this is an intentional citation to a retracted paper, please replace {{retracted|...}} with {{retracted|...|intentional=yes}}.)

[pmid17803194-7] Axton R, Wallis JA, Taylor H, Hanks M, Forrester LM (March 2008). "Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology". J. Cell. Biochem. 103 (4): 1171–82. doi:10.1002/jcb.21497. PMID 17803194. S2CID 11365605.

[pmid15544570-8] Albiston AL, Ye S, Chai SY (October 2004). "Membrane bound members of the M1 family: more than aminopeptidases". Protein Pept. Lett. 11 (5): 491–500. doi:10.2174/0929866043406643. PMID 15544570.