C17orf98 information

C17orf98
Identifiers
Aliases	C17orf98, chromosome 17 open reading frame 98
External IDs	MGI: 1919465; HomoloGene: 19140; GeneCards: C17orf98; OMA:C17orf98 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,841,438 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,666,744 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; gonad; ; mucosa of transverse colon; ; granulocyte; ; right adrenal cortex; ; left adrenal cortex; ; gastric mucosa; ; stromal cell of endometrium;
	Top expressed in
	seminiferous tubule; ; spermatid; ; blastocyst; ; spermatocyte; ; embryo; ; embryo; ; zygote; ; superior frontal gyrus; ; neural layer of retina; ; cerebellar cortex;
	More reference expression data
	n/a
Orthologs
	388381
	72215
	ENSG00000275489; ENSG00000276913
	ENSMUSG00000018543
	A8MV24
	Q9DAQ5
	NM_001080465
	NM_028156
	NP_001073934
	NP_082432
	Wikidata
View/Edit Human	View/Edit Mouse

C17orf98 is a protein which in humans is coded by the gene c17orf98. The protein is derived from Homo sapiens chromosome 17.^[5] The C17orf98 gene consists of a 6,302 base sequence. Its mRNA has three exons and no alternative splice sites. The protein has 154 amino acids, with no abnormal amino acid levels.^[6] C17orf98 has a domain of unknown function (DUF4542) and is 17.6kDa in weight.^[7]^[8] C17orf98 does not belong to any other families nor does it have any isoforms.^[9] The protein has orthologs with high percent similarity in mammals and reptiles. The protein has additional distantly related orthologs across the metazoan kingdom, culminating with the sponge family.^[10]

Like most proteins, C17orf98 is known to be highly expressed in the testes.^[11] The protein has also been known to have elevated levels in cancer.^[11] The protein has been shown to be expressed in proximity to or within intermediate filaments and the nucleolus.^[11] Additionally, c17orf98 has transcription factors which are also active in hematopoietic stem cells, the immune system, and the cardiovascular system, among others.^[12] The gene is over-expressed in many cancer types, including kidney renal clear cell carcinoma and lung squamous cell carcinoma.^[13] Motif and transcription factor analysis points towards c17orf98 playing a role in proliferation, specially in immune cell proliferation.

^ ^a ^b ^c ENSG00000276913 GRCh38: Ensembl release 89: ENSG00000275489, ENSG00000276913 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018543 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, et al. (April 2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
^ PSORT II entry on c17orf98 https://psort.hgc.jp/form2.html
^ NCBI Conserved Domains entry C17orf98
^ ENMBL-EBI SAPS entry on c17orf98
^ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2 May 2018.
^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2 May 2018.
^ ^a ^b ^c Human protein atlas entry on c17orf98
^ Genomatix El Derado etnry on c17orf98
^ TissGDB entry on c17orf98

[refGRCh38Ensembl-1] ENSG00000276913 GRCh38: Ensembl release 89: ENSG00000275489, ENSG00000276913 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018543 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16625196-5] Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, et al. (April 2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.

[6] PSORT II entry on c17orf98 https://psort.hgc.jp/form2.html

[7] NCBI Conserved Domains entry C17orf98

[ENMBL-EBI_SAPS_entry_on_c17orf98-8] ENMBL-EBI SAPS entry on c17orf98

[9] "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2 May 2018.

[nih.gov-10] "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2 May 2018.

[auto-11] Human protein atlas entry on c17orf98

[12] Genomatix El Derado etnry on c17orf98

[auto1-13] TissGDB entry on c17orf98

C17orf98 information

and 3 Related for: C17orf98 information

C17orf98

Chromosome 17

Transmembrane protein 89