C17orf75 information

C17orf75
Identifiers
Aliases	C17orf75, NJMU-R1, SRI2, chromosome 17 open reading frame 75
External IDs	MGI: 1917841; HomoloGene: 11177; GeneCards: C17orf75; OMA:C17orf75 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,350,023 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,268,860 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ganglionic eminence; ; right adrenal cortex; ; right uterine tube; ; ventricular zone; ; oocyte; ; left adrenal gland; ; anterior pituitary; ; left adrenal cortex;
	Top expressed in
	muscle of thigh; ; knee joint; ; dentate gyrus of hippocampal formation granule cell; ; Rostral migratory stream; ; triceps brachii muscle; ; quadriceps femoris muscle; ; superior frontal gyrus; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function; protein binding;
Cellular component	cellular component; trans-Golgi network; cytoplasmic vesicle; Golgi apparatus;
Biological process	intracellular protein transport; vesicle tethering to Golgi;
	Sources:Amigo / QuickGO
Orthologs
	64149
	70591
	ENSG00000108666
	ENSMUSG00000057181
	Q9HAS0
	Q9CYI0
	NM_022344
	NM_027472
	NP_071739
	NP_081748
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome 17 open reading frame 75 is a protein that in humans is encoded by the C17orf75 gene. ^[5] C17orf75 is also known as SRI2 (sensitization to ricin complex subunit 2) and is a human protein encoding gene located at 17q11.2 on the complementary strand.^[6] The protein this gene encodes is also known as NJMU-R1.^[7] The C17orf75 gene is ubiquitously expressed at medium-low levels throughout the body and at slightly higher levels in the brain and testes.^[8] This protein is thought to be part of a complex associated with golgin-mediated vesicle capture.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108666 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057181 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chromosome 17 open reading frame 75". Retrieved 2022-07-28.
^ "C17orf75 chromosome 17 open reading frame 75 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-07-30.
^ "C17orf75 Gene - GeneCards | NJMU Protein | NJMU Antibody". www.genecards.org. Retrieved 2022-07-30.
^ "C17orf75 chromosome 17 open reading frame 75 [Homo sapiens (human)] - Gene Expression - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-07-30.
^ Navarro Negredo, Paloma; Edgar, James R.; Manna, Paul T.; Antrobus, Robin; Robinson, Margaret S. (2018-02-09). "The WDR11 complex facilitates the tethering of AP-1-derived vesicles". Nature Communications. 9 (1): 596. Bibcode:2018NatCo...9..596N. doi:10.1038/s41467-018-02919-4. ISSN 2041-1723. PMC 5807400. PMID 29426865.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108666 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057181 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Chromosome 17 open reading frame 75". Retrieved 2022-07-28.

[6] "C17orf75 chromosome 17 open reading frame 75 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-07-30.

[7] "C17orf75 Gene - GeneCards | NJMU Protein | NJMU Antibody". www.genecards.org. Retrieved 2022-07-30.

[:0-8] "C17orf75 chromosome 17 open reading frame 75 [Homo sapiens (human)] - Gene Expression - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-07-30.

[9] Navarro Negredo, Paloma; Edgar, James R.; Manna, Paul T.; Antrobus, Robin; Robinson, Margaret S. (2018-02-09). "The WDR11 complex facilitates the tethering of AP-1-derived vesicles". Nature Communications. 9 (1): 596. Bibcode:2018NatCo...9..596N. doi:10.1038/s41467-018-02919-4. ISSN 2041-1723. PMC 5807400. PMID 29426865.